| 2024-03-31 | AVIDITY PARTNERS MANAGEMENT LP | 2.69% | 982K | 13.82M | 982K | +100.00% |
| 2024-03-31 | LOGOS GLOBAL MANAGEMENT LP | 2.74% | 1M | 14.08M | 1M | +100.00% |
| 2024-03-31 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 4.38% | 1.6M | 22.54M | 1.6M | +100.00% |
| 2024-03-31 | MILLENNIUM MANAGEMENT LLC | 4.57% | 1.67M | 23.47M | 1.45M | +657.60% |
| 2024-03-31 | STATE STREET CORP | 6.08% | 2.22M | 31.24M | 1.69M | +319.01% |
| 2024-03-31 | VIVO CAPITAL, LLC | 6.38% | 2.33M | 32.78M | -153.7K | -6.19% |
| 2024-03-31 | VANGUARD GROUP INC | 6.94% | 2.54M | 35.69M | 480.18K | +23.36% |
| 2024-03-31 | FAIRMOUNT FUNDS MANAGEMENT LLC | 9.73% | 3.55M | 50.02M | 0 | 0 |
| 2024-03-31 | BANK OF NEW YORK MELLON CORP | 0.36% | 130.11K | 1.83M | 37.85K | +41.03% |
| 2024-03-31 | RAFFERTY ASSET MANAGEMENT, LLC | 0.43% | 156.53K | 2.2M | 156.53K | +100.00% |
| 2024-03-31 | DRIEHAUS CAPITAL MANAGEMENT LLC | 4.83% | 1.76M | 24.84M | 1.34M | +314.93% |
| 2024-03-31 | VR ADVISER, LLC | 9.88% | 3.61M | 50.79M | 382.84K | +11.87% |
| 2024-03-31 | RA CAPITAL MANAGEMENT, L.P. | 12.08% | 4.41M | 62.12M | 4.41M | +100.00% |
| 2024-03-31 | TCG CROSSOVER MANAGEMENT, LLC | 14.45% | 5.28M | 74.3M | 5.28M | +100.00% |
| 2024-03-31 | PERCEPTIVE ADVISORS LLC | 17.76% | 6.49M | 91.25M | 2.48M | +61.97% |
| 2024-03-31 | GEODE CAPITAL MANAGEMENT, LLC | 2.74% | 1M | 14.1M | 304.53K | +43.68% |
| 2024-03-31 | VESTAL POINT CAPITAL, LP | 3.01% | 1.1M | 15.48M | 1.1M | +100.00% |
| 2024-03-31 | BLACKROCK INC. | 9.82% | 3.59M | 50.47M | 1.4M | +64.13% |
| 2024-03-31 | FMR LLC | 11.83% | 4.32M | 60.79M | -483.87K | -10.07% |
| 2024-03-31 | GHOST TREE CAPITAL, LLC | 0.31% | 115K | 1.62M | -220K | -65.67% |
| 2024-03-31 | WELLINGTON MANAGEMENT GROUP LLP | 0.32% | 116.06K | 1.63M | 116.06K | +100.00% |
| 2024-03-31 | TOROSO INVESTMENTS, LLC | 0.32% | 118.2K | 1.66M | 118.2K | +100.00% |
| 2024-03-31 | UBS GROUP AG | 0.35% | 126.05K | 1.77M | 89.88K | +248.47% |
| 2024-03-31 | PFM HEALTH SCIENCES, LP | 0.9% | 327.05K | 4.6M | 327.05K | +100.00% |
| 2024-03-31 | ARTAL GROUP S.A. | 2.42% | 884.21K | 12.45M | 884.21K | +100.00% |
| 2024-03-31 | CORMORANT ASSET MANAGEMENT, LP | 3.56% | 1.3M | 18.3M | 1.3M | +100.00% |
| 2024-03-31 | PACER ADVISORS, INC. | 0% | 732 | 10.3K | 732 | +100.00% |
| 2024-03-31 | STRS OHIO | 0% | 1.3K | 18K | 1.3K | +100.00% |
| 2024-03-31 | SIMPLEX TRADING, LLC | 0.26% | 96.68K | 1.36M | 81K | +516.59% |
| 2024-03-31 | RHUMBLINE ADVISERS | 0.17% | 62.82K | 884.17K | 25.21K | +67.03% |
| 2024-03-31 | ALLIANCEBERNSTEIN L.P. | 0.14% | 49.37K | 694.88K | 49.37K | +100.00% |
| 2024-03-31 | RENAISSANCE TECHNOLOGIES LLC | 0.11% | 41.4K | 583K | 27.2K | +191.55% |
| 2024-03-31 | BALYASNY ASSET MANAGEMENT L.P. | 0.1% | 37.74K | 531.15K | 37.74K | +100.00% |
| 2024-03-31 | ADVISOR GROUP HOLDINGS, INC. | 0.09% | 32.26K | 454.11K | 31.7K | +5,640.75% |
| 2024-03-31 | GROUP ONE TRADING, L.P. | 0.09% | 31.61K | 444.85K | 29.04K | +1,132.68% |
| 2024-03-31 | METLIFE INVESTMENT MANAGEMENT, LLC | 0.07% | 25.66K | 361.21K | 12.09K | +89.07% |
| 2024-03-31 | PROFUND ADVISORS LLC | 0.07% | 24.8K | 349M | 24.8K | +100.00% |
| 2024-03-31 | AMERICAN INTERNATIONAL GROUP, INC. | 0.07% | 24.57K | 345.75K | 8.12K | +49.39% |
| 2024-03-31 | JPMORGAN CHASE & CO | 0.05% | 19.48K | 274.15K | -2.4K | -10.99% |
| 2024-03-31 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0.05% | 17.16K | 241.47K | 2.23K | +14.95% |
| 2024-03-31 | WELLS FARGO & COMPANY/MN | 0.05% | 17.04K | 239.82K | -9.84K | -36.61% |
| 2024-03-31 | BELVEDERE TRADING LLC | 0.02% | 8.5K | 119.64K | 8.5K | +100.00% |
| 2024-03-31 | PANAGORA ASSET MANAGEMENT INC | 0.04% | 15.11K | 212.67K | -352 | -2.28% |
| 2024-03-31 | OPPENHEIMER & CO INC | 0.04% | 12.94K | 182.19K | -1.5K | -10.38% |
| 2024-03-31 | DIMENSIONAL FUND ADVISORS LP | 0.04% | 12.78K | 179.86K | 12.78K | +100.00% |
| 2024-03-31 | NEW YORK STATE COMMON RETIREMENT FUND | 0.03% | 12.65K | 178K | 2.41K | +23.57% |
| 2024-03-31 | LEGAL & GENERAL GROUP PLC | 0.01% | 5.06K | 71.19M | 1.57K | +44.85% |
| 2024-03-31 | AMERITAS INVESTMENT PARTNERS, INC. | 0.01% | 4.97K | 69.97M | 2.86K | +135.59% |
| 2024-03-31 | AMALGAMATED BANK | 0% | 1.68K | 24K | -1.77K | -51.20% |
| 2024-03-31 | METROPOLITAN LIFE INSURANCE CO/NY | 0.01% | 2.64K | 37.17K | 655 | +32.98% |
| 2024-03-31 | CUTLER GROUP LLC / CA | 0.01% | 4.9K | 2K | 4.9K | +100.00% |
| 2024-03-31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.36% | 131.07K | 1.84M | 44.29K | +51.03% |
| 2024-03-31 | BARCLAYS PLC | 0.37% | 135.21K | 1.9M | 85.79K | +173.62% |
| 2024-03-31 | IKARIAN CAPITAL, LLC | 0.39% | 140.69K | 1.98M | -234.12K | -62.46% |
| 2024-03-31 | ALTIUM CAPITAL MANAGEMENT LP | 0.39% | 142.53K | 2.01M | -587.47K | -80.48% |
| 2024-03-31 | CITIGROUP INC | 0.43% | 158.58K | 2.23M | 153.84K | +3,245.46% |
| 2024-03-31 | NUVEEN ASSET MANAGEMENT, LLC | 0.57% | 207.2K | 2.92M | 105.03K | +102.80% |
| 2024-03-31 | GOLDMAN SACHS GROUP INC | 0.58% | 213.53K | 3.01M | 197.16K | +1,203.94% |
| 2024-03-31 | DAFNA CAPITAL MANAGEMENT LLC | 0.61% | 223.27K | 3.14M | -225.74K | -50.28% |
| 2024-03-31 | MORGAN STANLEY | 0.62% | 225.56K | 3.17M | -151.98K | -40.26% |
| 2024-03-31 | STEMPOINT CAPITAL LP | 0.63% | 230.27K | 2.68M | -626.68K | -73.13% |
| 2024-03-31 | INVESCO LTD. | 0.81% | 295.45K | 4.16M | 283.96K | +2,471.81% |
| 2024-03-31 | HAP TRADING, LLC | 0.84% | 306.7K | 315K | 306.7K | +100.00% |
| 2024-03-31 | TRI LOCUM PARTNERS LP | 1.01% | 369.55K | 5.2M | -173.4K | -31.94% |
| 2024-03-31 | SIO CAPITAL MANAGEMENT, LLC | 1.12% | 410.27K | 5.77M | 410.27K | +100.00% |
| 2024-03-31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1.16% | 424.1K | 5.97M | 424.1K | +100.00% |
| 2024-03-31 | NORTHERN TRUST CORP | 1.18% | 429.89K | 6.05M | 126.79K | +41.83% |
| 2024-03-31 | AFFINITY ASSET ADVISORS, LLC | 2.32% | 845.61K | 11.9M | -620.86K | -42.34% |
| 2024-03-31 | CITADEL ADVISORS LLC | 0.42% | 152.8K | 2.15M | 132K | +634.62% |
| 2024-03-31 | CAPTION MANAGEMENT, LLC | 0.82% | 300K | 4.22M | 300K | +100.00% |
| 2023-12-31 | TREXQUANT INVESTMENT LP | 0.19% | 53.2K | 408.61K | 53.2K | +100.00% |
| 2023-12-31 | PERCEPTIVE ADVISORS LLC | 14.28% | 4M | 30.75M | 1.81M | +82.88% |
| 2023-12-31 | FAIRMOUNT FUNDS MANAGEMENT LLC | 12.68% | 3.55M | 27.3M | 1.65M | +86.92% |
| 2023-12-31 | VR ADVISER, LLC | 11.5% | 3.23M | 24.77M | 3.23M | +100.00% |
| 2023-12-31 | VIVO CAPITAL, LLC | 8.85% | 2.48M | 19.07M | 801.53K | +47.68% |
| 2023-12-31 | BLACKROCK INC. | 7.79% | 2.18M | 16.78M | 495.72K | +29.35% |
| 2023-12-31 | VANGUARD GROUP INC | 7.33% | 2.06M | 15.79M | 545.79K | +36.15% |
| 2023-12-31 | ARMISTICE CAPITAL, LLC | 5.63% | 1.58M | 12.12M | 1.58M | +100.00% |
| 2023-12-31 | AFFINITY ASSET ADVISORS, LLC | 5.23% | 1.47M | 11.26M | 466.17K | +46.60% |
| 2023-12-31 | SPHERA FUNDS MANAGEMENT LTD. | 4.11% | 1.15M | 8.84M | 570.55K | +98.27% |
| 2023-12-31 | ROSALIND ADVISORS, INC. | 4.03% | 1.13M | 8.67M | 1.13M | +100.00% |
| 2023-12-31 | SATURN V CAPITAL MANAGEMENT LLC | 3.53% | 990.66K | 7.61M | -228.43K | -18.74% |
| 2023-12-31 | | 0.68% | 191.25K | 1.47M | 191.25K | +100.00% |
| 2023-12-31 | ALTIUM CAPITAL MANAGEMENT LP | 2.6% | 730K | 5.61M | -617.09K | -45.81% |
| 2023-12-31 | GEODE CAPITAL MANAGEMENT, LLC | 2.49% | 697.22K | 5.36M | 198.37K | +39.77% |
| 2023-12-31 | LOGOS GLOBAL MANAGEMENT LP | 1.94% | 544.96K | 4.19M | 0 | 0 |
| 2023-12-31 | TRI LOCUM PARTNERS LP | 1.94% | 542.95K | 4.17M | -55.18K | -9.23% |
| 2023-12-31 | STATE STREET CORP | 1.89% | 529.75K | 4.07M | 35.69K | +7.22% |
| 2023-12-31 | DAFNA CAPITAL MANAGEMENT LLC | 1.6% | 449.01K | 3.45M | 153.52K | +51.95% |
| 2023-12-31 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1.52% | 425.36K | 3.27M | -1.03M | -70.75% |
| 2023-12-31 | MORGAN STANLEY | 1.35% | 377.54K | 2.9M | 344.19K | +1,032.05% |
| 2023-12-31 | IKARIAN CAPITAL, LLC | 1.34% | 374.81K | 2.88M | 0 | 0 |
| 2023-12-31 | GHOST TREE CAPITAL, LLC | 1.19% | 335K | 2.57M | 35K | +11.67% |
| 2023-12-31 | NORTHERN TRUST CORP | 1.08% | 303.1K | 2.33M | 58.75K | +24.04% |
| 2023-12-31 | MILLENNIUM MANAGEMENT LLC | 0.79% | 220.13K | 1.69M | 220.13K | +100.00% |
| 2023-12-31 | JACOBS LEVY EQUITY MANAGEMENT, INC | 0.54% | 152.73K | 1.17M | -8.91K | -5.51% |
| 2023-12-31 | NUVEEN ASSET MANAGEMENT, LLC | 0.36% | 102.17K | 784.64K | 2.29K | +2.29% |
| 2023-12-31 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0.34% | 96.3K | 739.59K | 31.1K | +47.70% |
| 2023-12-31 | BANK OF NEW YORK MELLON CORP | 0.33% | 92.25K | 708.5K | 22.5K | +32.26% |
| 2023-12-31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.31% | 86.78K | 666.49K | 18.56K | +27.20% |
| 2023-12-31 | WEISS MULTI-STRATEGY ADVISERS LLC | 0.29% | 80K | 614K | 29.46K | +58.29% |
| 2023-12-31 | UBS OCONNOR LLC | 0.28% | 78.12K | 599.96K | -45.88K | -37.00% |
| 2023-12-31 | BOOTHBAY FUND MANAGEMENT, LLC | 0.22% | 61.94K | 475.72K | 0 | 0 |
| 2023-12-31 | BANK OF AMERICA CORP /DE/ | 0.2% | 54.96K | 422.12K | 21.38K | +63.66% |
| 2023-12-31 | FMR LLC | 17.13% | 4.8M | 36.89M | 2.24M | +87.25% |
| 2023-12-31 | JEFFERIES FINANCIAL GROUP INC. | 0.18% | 50K | 384K | 50K | +100.00% |
| 2023-12-31 | BARCLAYS PLC | 0.18% | 49.41K | 379K | 41K | +487.00% |
| 2023-12-31 | JANE STREET GROUP, LLC | 0.14% | 40.08K | 307.79K | 40.08K | +100.00% |
| 2023-12-31 | RHUMBLINE ADVISERS | 0.13% | 37.61K | 288.84K | 5.81K | +18.27% |
| 2023-12-31 | UBS GROUP AG | 0.13% | 36.17K | 277.8K | 23.25K | +179.82% |
| 2023-12-31 | SCHONFELD STRATEGIC ADVISORS LLC | 0.13% | 36.1K | 277.25K | -11.4K | -24.00% |
| 2023-12-31 | TWO SIGMA INVESTMENTS, LP | 0.12% | 34.05K | 261.48K | 34.05K | +100.00% |
| 2023-12-31 | XTX TOPCO LTD | 0.1% | 28.72K | 220.54K | 28.72K | +100.00% |
| 2023-12-31 | WELLS FARGO & COMPANY/MN | 0.1% | 26.88K | 206.44K | 21.46K | +395.48% |
| 2023-12-31 | JPMORGAN CHASE & CO | 0.08% | 21.88K | 168.05K | 4.55K | +26.22% |
| 2023-12-31 | CITADEL ADVISORS LLC | 0.07% | 20.8K | 159.74K | 12.6K | +153.66% |
| 2023-12-31 | ALYESKA INVESTMENT GROUP, L.P. | 0.07% | 20.77K | 159.52K | 20.77K | +100.00% |
| 2023-12-31 | DEUTSCHE BANK AG\ | 0.06% | 16.62K | 127.63K | 0 | 0 |
| 2023-09-30 | ADVISOR GROUP HOLDINGS, INC. | 0% | 562 | - | 0 | 0 |
| 2023-09-30 | SIMPLEX TRADING, LLC | 0% | 1.07K | - | 803 | +306.49% |
| 2023-09-30 | METROPOLITAN LIFE INSURANCE CO/NY | 0.01% | 1.41K | - | 0 | 0 |
| 2023-09-30 | AMERITAS INVESTMENT PARTNERS, INC. | 0.01% | 2.11K | - | 0 | 0 |
| 2023-09-30 | GROUP ONE TRADING, L.P. | 0.01% | 3.2K | - | 3.2K | +100.00% |
| 2023-09-30 | TOWER RESEARCH CAPITAL LLC (TRC) | 0.01% | 3.36K | - | 2.71K | +416.46% |
| 2023-09-30 | ROYAL BANK OF CANADA | 0.01% | 3.63K | - | 998 | +37.87% |
| 2023-09-30 | AMALGAMATED BANK | 0.01% | 3.71K | - | 0 | 0 |
| 2023-09-30 | WELLS FARGO & COMPANY/MN | 0.02% | 5.43K | - | -5.11K | -48.51% |
| 2023-09-30 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0.02% | 5.64K | - | -2.86K | -33.67% |
| 2023-09-30 | BARCLAYS PLC | 0.03% | 8.42K | - | -592 | -6.57% |
| 2023-09-30 | NEW YORK STATE COMMON RETIREMENT FUND | 0.04% | 10.28K | - | 281 | +2.81% |
| 2023-09-30 | VOYA INVESTMENT MANAGEMENT LLC | 0.04% | 10.44K | - | 0 | 0 |
| 2023-09-30 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0.04% | 10.61K | - | 0 | 0 |
| 2023-09-30 | AMERICAN INTERNATIONAL GROUP, INC. | 0.05% | 12.75K | - | 453 | +3.68% |
| 2023-09-30 | UBS GROUP AG | 0.05% | 12.93K | - | -1.86K | -12.57% |
| 2023-09-30 | MIRAE ASSET GLOBAL INVESTMENTS CO., LTD. | 0.05% | 13.5K | - | 0 | 0 |
| 2023-09-30 | METLIFE INVESTMENT MANAGEMENT, LLC | 0.05% | 13.57K | - | 0 | 0 |
| 2023-09-30 | OPPENHEIMER & CO INC | 0.05% | 14.53K | - | 0 | 0 |
| 2023-09-30 | JUMP FINANCIAL, LLC | 0.05% | 14.93K | - | 14.93K | +100.00% |
| 2023-09-30 | DEUTSCHE BANK AG\ | 0.06% | 16.62K | - | 3.42K | +25.93% |
| 2023-09-30 | WALLEYE CAPITAL LLC | 0.07% | 19.53K | - | 19.53K | +100.00% |
| 2023-09-30 | INVESCO LTD. | 0.09% | 23.91K | - | 11.25K | +88.88% |
| 2023-09-30 | GOLDMAN SACHS GROUP INC | 0.1% | 28.53K | - | 2.9K | +11.30% |
| 2023-09-30 | RHUMBLINE ADVISERS | 0.11% | 31.8K | - | 1.67K | +5.53% |
| 2023-09-30 | MORGAN STANLEY | 0.12% | 33.35K | - | -20.59K | -38.18% |
| 2023-09-30 | CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD. | 0.15% | 42.07K | - | -10.59K | -20.11% |
| 2023-09-30 | STRATOS WEALTH PARTNERS, LTD. | 0.15% | 42.19K | - | -20.43K | -32.62% |
| 2023-09-30 | SCHONFELD STRATEGIC ADVISORS LLC | 0.17% | 47.5K | - | 1K | +2.15% |
| 2023-09-30 | WEISS MULTI-STRATEGY ADVISERS LLC | 0.18% | 50.54K | - | -173.71K | -77.46% |
| 2023-09-30 | ENSIGN PEAK ADVISORS, INC | 0.23% | 65K | - | 0 | 0 |
| 2023-09-30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.24% | 68.22K | - | 0 | 0 |
| 2023-09-30 | BANK OF NEW YORK MELLON CORP | 0.25% | 69.75K | - | 330 | +0.48% |
| 2023-09-30 | NUVEEN ASSET MANAGEMENT, LLC | 0.36% | 99.88K | - | 8.49K | +9.28% |
| 2023-09-30 | POLAR ASSET MANAGEMENT PARTNERS INC. | 0.55% | 154.2K | - | 0 | 0 |
| 2023-09-30 | JACOBS LEVY EQUITY MANAGEMENT, INC | 0.58% | 161.64K | - | 31.86K | +24.55% |
| 2023-09-30 | NORTHERN TRUST CORP | 0.87% | 244.35K | - | 116 | +0.05% |
| 2023-09-30 | DAFNA CAPITAL MANAGEMENT LLC | 1.05% | 295.49K | - | 167.84K | +131.48% |
| 2023-09-30 | IKARIAN CAPITAL, LLC | 1.34% | 374.81K | - | -204.58K | -35.31% |
| 2023-09-30 | GEODE CAPITAL MANAGEMENT, LLC | 1.78% | 498.85K | - | 30.87K | +6.60% |
| 2023-09-30 | SPHERA FUNDS MANAGEMENT LTD. | 2.07% | 580.6K | - | 109.58K | +23.26% |
| 2023-09-30 | TRI LOCUM PARTNERS LP | 2.13% | 598.13K | - | 374.05K | +166.93% |
| 2023-09-30 | SATURN V CAPITAL MANAGEMENT LLC | 4.35% | 1.22M | - | 581.24K | +91.12% |
| 2023-09-30 | ALTIUM CAPITAL MANAGEMENT LP | 4.81% | 1.35M | - | 0 | 0 |
| 2023-09-30 | DRIEHAUS CAPITAL MANAGEMENT LLC | 5.19% | 1.45M | - | -1.44K | -0.10% |
| 2023-09-30 | VIVO CAPITAL, LLC | 6% | 1.68M | - | 0 | 0 |
| 2023-09-30 | BLACKROCK INC. | 6.03% | 1.69M | - | 36.33K | +2.20% |
| 2023-09-30 | FAIRMOUNT FUNDS MANAGEMENT LLC | 6.79% | 1.9M | - | 0 | 0 |
| 2023-09-30 | PERCEPTIVE ADVISORS LLC | 7.81% | 2.19M | - | 0 | 0 |
| 2023-09-30 | FMR LLC | 9.15% | 2.57M | - | -397.24K | -13.41% |
