| 2024-03-31 | NEA MANAGEMENT COMPANY, LLC | 1.94% | 1.59M | 180.41M | 0 | 0 |
| 2024-03-31 | ALLSPRING GLOBAL INVESTMENTS HOLDINGS, LLC | 0.1% | 78.92K | 5.38M | 41.9K | +113.19% |
| 2024-03-31 | BANK OF NEW YORK MELLON CORP | 0.1% | 75.31K | 5.13M | -32.58K | -30.20% |
| 2024-03-31 | VAN ECK ASSOCIATES CORP | 0.09% | 71.94K | 4.9M | 4.1K | +6.05% |
| 2024-03-31 | STATE STREET CORP | 1.89% | 1.5M | 101.91M | -258.29K | -14.73% |
| 2024-03-31 | ECOR1 CAPITAL, LLC | 1.7% | 1.39M | 94.69M | 1.39M | +100.00% |
| 2024-03-31 | MORGAN STANLEY | 1.37% | 1.09M | 74.02M | 672.85K | +162.89% |
| 2024-03-31 | CREDIT SUISSE AG/ | 0.91% | 719.31K | 49.03M | -156.84K | -17.90% |
| 2024-03-31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.84% | 669.19K | 45.61M | 16.17K | +2.48% |
| 2024-03-31 | CONTRARIUS INVESTMENT MANAGEMENT LTD | 0.81% | 666K | 45.4M | 483.07K | +264.08% |
| 2024-03-31 | BELLEVUE GROUP AG | 0.76% | 619.95K | 42.26M | -280.45K | -31.15% |
| 2024-03-31 | PRICE T ROWE ASSOCIATES INC /MD/ | 0.76% | 600.23K | 40.91M | -264.11K | -30.56% |
| 2024-03-31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.71% | 565.5K | 38.54M | 123.2K | +27.85% |
| 2024-03-31 | VERSANT VENTURE MANAGEMENT, LLC | 0.61% | 498.56K | 33.98M | 0 | 0 |
| 2024-03-31 | FEDERATED HERMES, INC. | 0.57% | 447.61K | 30.51M | -60.49K | -11.91% |
| 2024-03-31 | AVORO CAPITAL ADVISORS LLC | 0.51% | 419.58K | 28.6M | 419.58K | +100.00% |
| 2024-03-31 | JPMORGAN CHASE & CO | 0.5% | 392.75K | 26.77M | -70.52K | -15.22% |
| 2024-03-31 | BAILLIE GIFFORD & CO | 0.48% | 395.92K | 26.99M | -26.85K | -6.35% |
| 2024-03-31 | CAPTION MANAGEMENT, LLC | 0.36% | 295K | 20.11M | -105K | -26.25% |
| 2024-03-31 | UBS GROUP AG | 0.4% | 320.38K | 21.84M | 9.47K | +3.05% |
| 2024-03-31 | PICTET ASSET MANAGEMENT HOLDING SA | 0.39% | 320.52K | 22.16M | 311.85K | +3,595.22% |
| 2024-03-31 | PEAK6 INVESTMENTS LLC | 0.35% | 288.1K | 19.64M | 265.6K | +1,180.44% |
| 2024-03-31 | SQUAREPOINT OPS LLC | 0.34% | 274.03K | 18.68M | 146.67K | +115.17% |
| 2024-03-31 | BARCLAYS PLC | 0.32% | 256.33K | 17.47M | -56.63K | -18.10% |
| 2024-03-31 | CAPITAL ADVISORS INC/OK | 0.32% | 263.99K | 17.99M | 8.72K | +3.42% |
| 2024-03-31 | NORTHERN TRUST CORP | 0.31% | 243.28K | 16.58M | -7.16K | -2.86% |
| 2024-03-31 | VESTMARK ADVISORY SOLUTIONS, INC. | 0.31% | 249.54K | 17.01M | 76.26K | +44.01% |
| 2024-03-31 | CITADEL ADVISORS LLC | 0.3% | 237.1K | 16.16M | -36.26K | -13.26% |
| 2024-03-31 | WELLS FARGO & COMPANY/MN | 0.27% | 216.39K | 14.75M | 48K | +28.50% |
| 2024-03-31 | INTEGRAL HEALTH ASSET MANAGEMENT, LLC | 0.27% | 220K | 15M | 220K | +100.00% |
| 2024-03-31 | EAGLE HEALTH INVESTMENTS LP | 0.24% | 197K | 13.43M | 197K | +100.00% |
| 2024-03-31 | ARMISTICE CAPITAL, LLC | 0.23% | 192K | 13.09M | 24K | +14.29% |
| 2024-03-31 | CAPITAL FUND MANAGEMENT S.A. | 0.23% | 188.5K | 12.85M | 167.3K | +789.15% |
| 2024-03-31 | JANE STREET GROUP, LLC | 0.22% | 175.07K | 11.93M | -299.94K | -63.14% |
| 2024-03-31 | D. E. SHAW & CO., INC. | 0.22% | 174.3K | 11.88M | 137.02K | +367.63% |
| 2024-03-31 | SR ONE CAPITAL MANAGEMENT, LP | 1.28% | 1.05M | 71.5M | 1.05M | +100.00% |
| 2024-03-31 | LOOMIS SAYLES & CO L P | 1.25% | 1.03M | 69.88M | -42.11K | -3.95% |
| 2024-03-31 | DIMENSIONAL FUND ADVISORS LP | 1.18% | 931.06K | 63.46M | 151.6K | +19.45% |
| 2024-03-31 | GEODE CAPITAL MANAGEMENT, LLC | 1.15% | 909.3K | 62M | 25.57K | +2.89% |
| 2024-03-31 | BANK OF AMERICA CORP /DE/ | 1.09% | 863.21K | 58.84M | 172.04K | +24.89% |
| 2024-03-31 | ARK INVESTMENT MANAGEMENT LLC | 9.97% | 8.16M | 555.98M | -379.08K | -4.44% |
| 2024-03-31 | CAPITAL INTERNATIONAL INVESTORS | 9.58% | 7.84M | 534.17M | 1.7M | +27.76% |
| 2024-03-31 | SUMITOMO MITSUI TRUST HOLDINGS, INC. | 4% | 3.27M | 222.8M | -100.98K | -3.00% |
| 2024-03-31 | NIKKO ASSET MANAGEMENT AMERICAS, INC. | 4% | 3.27M | 222.7M | -100.98K | -3.00% |
| 2024-03-31 | T. ROWE PRICE INVESTMENT MANAGEMENT, INC. | 3.31% | 2.7M | 184.33M | -906.86K | -25.11% |
| 2024-03-31 | BLACKROCK INC. | 3.21% | 2.55M | 173.56M | 29.88K | +1.19% |
| 2024-03-31 | FMR LLC | 2.83% | 2.24M | 152.66M | 399.81K | +21.73% |
| 2024-03-31 | VANGUARD GROUP INC | 2.07% | 1.64M | 111.56M | 46.15K | +2.90% |
| 2024-03-31 | TD ASSET MANAGEMENT INC | 0.21% | 166.79K | 11.37B | -59.07K | -26.15% |
| 2024-03-31 | MIRAE ASSET GLOBAL INVESTMENTS CO., LTD. | 0.21% | 166.55K | 7.45M | 77.05K | +86.10% |
| 2024-03-31 | BNP PARIBAS ARBITRAGE, SNC | 0.19% | 148.94K | 10.15M | 106.65K | +252.19% |
| 2024-03-31 | SWISS NATIONAL BANK | 0.19% | 148.9K | 10.15M | 200 | +0.13% |
| 2024-03-31 | NORDEA INVESTMENT MANAGEMENT AB | 0.19% | 148.7K | 10.3M | 43.1K | +40.81% |
| 2024-03-31 | BLAIR WILLIAM & CO/IL | 0.19% | 147.89K | 10.08M | 11.19K | +8.19% |
| 2024-03-31 | CAPITAL INTERNATIONAL SARL | 0.18% | 141.91K | 9.67M | 39.23K | +38.21% |
| 2024-03-31 | CAPITAL INTERNATIONAL LTD /CA/ | 0.16% | 126.77K | 8.64M | 31.91K | +33.64% |
| 2024-03-31 | RAFFERTY ASSET MANAGEMENT, LLC | 0.16% | 123.57K | 8.42M | -23.76K | -16.13% |
| 2024-03-31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 0.14% | 107.73K | 7.34M | 0 | 0 |
| 2024-03-31 | LPL FINANCIAL LLC | 0.13% | 105.92K | 7.22M | 13.46K | +14.56% |
| 2024-03-31 | CITIGROUP INC | 0.13% | 101.47K | 6.92M | -9.62K | -8.66% |
| 2024-03-31 | BAKER CHAD R | 0.12% | 98.52K | 6.72M | 0 | 0 |
| 2024-03-31 | REYNDERS MCVEIGH CAPITAL MANAGEMENT, LLC | 0.12% | 96.98K | 6.61M | 4.93K | +5.36% |
| 2024-03-31 | CAPITAL INTERNATIONAL, INC./CA/ | 0.12% | 91.66K | 6.25M | 23.01K | +33.51% |
| 2024-03-31 | ADVISOR GROUP HOLDINGS, INC. | 0.11% | 91.05K | 6.2M | 582 | +0.64% |
| 2024-03-31 | LAZARD ASSET MANAGEMENT LLC | 0.11% | 86.14K | 5.87M | -10.94K | -11.27% |
| 2024-03-31 | LEGAL & GENERAL GROUP PLC | 0.1% | 82.91K | 5.65B | 15.85K | +23.63% |
| 2024-03-31 | ROCKEFELLER CAPITAL MANAGEMENT L.P. | 0.1% | 79.12K | 5.39M | -975 | -1.22% |
| 2023-12-31 | IKARIAN CAPITAL, LLC | 0.82% | 649.4K | 40.65M | 647.36K | +31,748.95% |
| 2023-12-31 | NORGES BANK | 0.78% | 617.59K | 38.66M | 617.59K | +100.00% |
| 2023-12-31 | CAPTION MANAGEMENT, LLC | 0.5% | 400K | 25.04M | 370K | +1,233.33% |
| 2023-12-31 | FEDERATED HERMES, INC. | 0.64% | 508.1K | 31.81M | 0 | 0 |
| 2023-12-31 | VERSANT VENTURE MANAGEMENT, LLC | 0.63% | 498.56K | 31.21M | 0 | 0 |
| 2023-12-31 | JANE STREET GROUP, LLC | 0.6% | 475.01K | 29.74M | 349.89K | +279.64% |
| 2023-12-31 | JPMORGAN CHASE & CO | 0.58% | 463.27K | 29M | -57.16K | -10.98% |
| 2023-12-31 | BAILLIE GIFFORD & CO | 0.53% | 422.76K | 26.46M | -18.3K | -4.15% |
| 2023-12-31 | MORGAN STANLEY | 0.52% | 413.08K | 25.86M | 61.64K | +17.54% |
| 2023-12-31 | UBS GROUP AG | 0.39% | 310.91K | 19.46M | -26.23K | -7.78% |
| 2023-12-31 | YIHENG CAPITAL MANAGEMENT, L.P. | 0.35% | 274.1K | 17.16M | 274.1K | +100.00% |
| 2023-12-31 | CAPITAL ADVISORS INC/OK | 0.32% | 255.27K | 15.98M | 23.34K | +10.06% |
| 2023-12-31 | FRONTIER CAPITAL MANAGEMENT CO LLC | 0.32% | 254.97K | 15.96M | -10.16K | -3.83% |
| 2023-12-31 | NORTHERN TRUST CORP | 0.32% | 250.43K | 15.68M | 6.19K | +2.53% |
| 2023-12-31 | MAN GROUP PLC | 0.3% | 235.88K | 14.77M | 57.94K | +32.56% |
| 2023-12-31 | TD ASSET MANAGEMENT INC | 0.28% | 225.86K | 14.14M | -14.6K | -6.07% |
| 2023-12-31 | TANG CAPITAL MANAGEMENT LLC | 0.27% | 215K | 13.46M | 215K | +100.00% |
| 2023-12-31 | GOLDMAN SACHS GROUP INC | 0.24% | 187.62K | 11.75M | 63.58K | +51.25% |
| 2023-12-31 | CONTRARIUS INVESTMENT MANAGEMENT LTD | 0.23% | 182.93K | 11.45M | -37.81K | -17.13% |
| 2023-12-31 | VESTMARK ADVISORY SOLUTIONS, INC. | 0.22% | 173.29K | 10.85M | 173.29K | +100.00% |
| 2023-12-31 | WELLS FARGO & COMPANY/MN | 0.21% | 168.4K | 10.54M | -34.84K | -17.14% |
| 2023-12-31 | ARMISTICE CAPITAL, LLC | 0.21% | 168K | 10.52M | -432.01K | -72.00% |
| 2023-12-31 | | 0.21% | 165K | 10.33M | 165K | +100.00% |
| 2023-12-31 | D. E. SHAW & CO., INC. | 0.2% | 160.9K | 10.07M | 68.4K | +73.95% |
| 2023-12-31 | BOOTHBAY FUND MANAGEMENT, LLC | 0.2% | 159.5K | 9.98M | 114.8K | +256.82% |
| 2023-12-31 | BARCLAYS PLC | 0.19% | 152K | 9.52M | 152K | +100.00% |
| 2023-12-31 | ARK INVESTMENT MANAGEMENT LLC | 10.75% | 8.54M | 534.36M | 1.37M | +19.17% |
| 2023-12-31 | CAPITAL INTERNATIONAL INVESTORS | 7.72% | 6.13M | 384.02M | 48.94K | +0.80% |
| 2023-12-31 | T. ROWE PRICE INVESTMENT MANAGEMENT, INC. | 4.55% | 3.61M | 226.06M | -40.65K | -1.11% |
| 2023-12-31 | SUMITOMO MITSUI TRUST HOLDINGS, INC. | 4.24% | 3.37M | 210.95M | -95.71K | -2.76% |
| 2023-12-31 | NIKKO ASSET MANAGEMENT AMERICAS, INC. | 4.24% | 3.37M | 210.91M | -95.71K | -2.76% |
| 2023-12-31 | BLACKROCK INC. | 3.17% | 2.52M | 157.53M | -196.72K | -7.25% |
| 2023-12-31 | FMR LLC | 2.32% | 1.84M | 115.18M | -217.54K | -10.57% |
| 2023-12-31 | STATE STREET CORP | 2.21% | 1.75M | 109.77M | -131.48K | -6.97% |
| 2023-12-31 | VANGUARD GROUP INC | 2% | 1.59M | 99.57M | 51.93K | +3.37% |
| 2023-12-31 | NEA MANAGEMENT COMPANY, LLC | 2% | 1.59M | 99.4M | 0 | 0 |
| 2023-12-31 | LOOMIS SAYLES & CO L P | 1.34% | 1.07M | 66.82M | -29K | -2.65% |
| 2023-12-31 | BELLEVUE GROUP AG | 1.13% | 900.4K | 56.37M | 2K | +0.22% |
| 2023-12-31 | GEODE CAPITAL MANAGEMENT, LLC | 1.11% | 883.73K | 55.33M | 33.79K | +3.98% |
| 2023-12-31 | CREDIT SUISSE AG/ | 1.1% | 876.15K | 54.85M | 3.21K | +0.37% |
| 2023-12-31 | PRICE T ROWE ASSOCIATES INC /MD/ | 1.09% | 864.35K | 54.11M | -5.29K | -0.61% |
| 2023-12-31 | DIMENSIONAL FUND ADVISORS LP | 0.98% | 779.45K | 48.8M | -100.35K | -11.41% |
| 2023-12-31 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0.92% | 726.89K | 45.5M | 726.89K | +100.00% |
| 2023-12-31 | BANK OF AMERICA CORP /DE/ | 0.87% | 691.17K | 43.27M | 11.47K | +1.69% |
| 2023-12-31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.82% | 653.02K | 40.88M | 15.09K | +2.36% |
| 2023-12-31 | SWISS NATIONAL BANK | 0.19% | 148.7K | 9.31M | -16.1K | -9.77% |
| 2023-12-31 | CITADEL ADVISORS LLC | 0.34% | 273.36K | 17.11M | 251.8K | +1,168.19% |
