| Mar 31, 2024 | VENBIO PARTNERS LLC | 6.36% | 2.7M | 13.83M | -218.12K | -7.48% |
| Mar 31, 2024 | MORGAN STANLEY | 0.07% | 28.07K | 144.01K | 24.65K | +719.14% |
| Mar 31, 2024 | BREVAN HOWARD CAPITAL MANAGEMENT LP | 0.07% | 28.36K | 145.48K | 28.36K | +100.00% |
| Mar 31, 2024 | BOOTHBAY FUND MANAGEMENT, LLC | 0.09% | 39.38K | 202K | -217.34K | -84.66% |
| Mar 31, 2024 | POLAR ASSET MANAGEMENT PARTNERS INC. | 0.13% | 54.7K | 280.61K | 54.7K | +100.00% |
| Mar 31, 2024 | NORTHERN TRUST CORP | 0.15% | 64.8K | 332.41K | 20.26K | +45.50% |
| Mar 31, 2024 | DIMENSIONAL FUND ADVISORS LP | 0.16% | 68.35K | 350.63K | 68.35K | +100.00% |
| Mar 31, 2024 | SQUAREPOINT OPS LLC | 0.16% | 69.3K | 355.51K | 69.3K | +100.00% |
| Mar 31, 2024 | JANE STREET GROUP, LLC | 0.19% | 78.9K | 404.76K | 78.9K | +100.00% |
| Mar 31, 2024 | PRELUDE CAPITAL MANAGEMENT, LLC | 0.24% | 100.3K | 514.55K | 100.3K | +100.00% |
| Mar 31, 2024 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0.25% | 106.5K | 546.35K | 106.5K | +100.00% |
| Mar 31, 2024 | STATE STREET CORP | 0.26% | 110.6K | 567.38K | 68.5K | +162.71% |
| Mar 31, 2024 | CITIGROUP INC | 0.28% | 119.51K | 613.08K | 119.51K | +100.00% |
| Mar 31, 2024 | HRT FINANCIAL LP | 0.31% | 133.27K | 683K | 133.27K | +100.00% |
| Mar 31, 2024 | LAURION CAPITAL MANAGEMENT LP | 2.1% | 888.89K | 4.56M | 888.89K | +100.00% |
| Mar 31, 2024 | ORBIMED ADVISORS LLC | 2.22% | 941.28K | 4.83M | -558.73K | -37.25% |
| Mar 31, 2024 | AFFINITY ASSET ADVISORS, LLC | 2.99% | 1.27M | 6.51M | 1.27M | +100.00% |
| Mar 31, 2024 | ARTAL GROUP S.A. | 3.57% | 1.51M | 7.76M | 1.51M | +100.00% |
| Mar 31, 2024 | VANGUARD GROUP INC | 3.61% | 1.53M | 7.86M | 360.8K | +30.80% |
| Mar 31, 2024 | AISLING CAPITAL MANAGEMENT LP | 6.68% | 2.83M | 14.54M | 0 | 0 |
| Mar 31, 2024 | QIMING U.S. VENTURES MANAGEMENT, LLC | 0% | 0 | - | -2.37M | -100.00% |
| Mar 31, 2024 | ANNANDALE CAPITAL, LLC | 0% | 0 | - | -50K | -100.00% |
| Mar 31, 2024 | RENAISSANCE TECHNOLOGIES LLC | 0% | 0 | - | -441.49K | -100.00% |
| Mar 31, 2024 | WELLS FARGO & COMPANY/MN | 0% | 245 | 1.26K | 4 | +1.66% |
| Mar 31, 2024 | MACQUARIE GROUP LTD | 0% | 1.27K | 7 | 1.27K | +100.00% |
| Mar 31, 2024 | BALYASNY ASSET MANAGEMENT L.P. | 7.2% | 3.06M | 15.67M | 3.06M | +100.00% |
| Mar 31, 2024 | VELAN CAPITAL INVESTMENT MANAGEMENT LP | 1.17% | 497.3K | 2.55M | 0 | 0 |
| Mar 31, 2024 | JPMORGAN CHASE & CO | 0.32% | 137.21K | 703.88K | 136.97K | +56,833.20% |
| Mar 31, 2024 | MARSHALL WACE, LLP | 0.31% | 132.7K | 680.73K | 132.7K | +100.00% |
| Mar 31, 2024 | UBS GROUP AG | 0.29% | 122.57K | 628.76K | -5.9K | -4.59% |
| Mar 31, 2024 | MAN GROUP PLC | 0.29% | 121.23K | 621.92K | 121.23K | +100.00% |
| Mar 31, 2024 | AMERICAN CENTURY COMPANIES INC | 0.07% | 31.62K | 162.21K | 31.62K | +100.00% |
| Mar 31, 2024 | WALLEYE CAPITAL LLC | 1.85% | 786.58K | 4.04M | 786.58K | +100.00% |
| Mar 31, 2024 | Y-INTERCEPT (HONG KONG) LTD | 0.05% | 21.81K | 111.86K | 21.81K | +100.00% |
| Mar 31, 2024 | JEFFERIES FINANCIAL GROUP INC. | 0.04% | 18.3K | 93.88K | 18.3K | +100.00% |
| Mar 31, 2024 | PALUMBO WEALTH MANAGEMENT LLC | 0.04% | 17.74K | 91.02K | 17.74K | +100.00% |
| Mar 31, 2024 | CAMBRIDGE INVESTMENT RESEARCH ADVISORS, INC. | 0.04% | 16.24K | 83K | 16.24K | +100.00% |
| Mar 31, 2024 | AMERITAS ADVISORY SERVICES, LLC | 0.04% | 15.5K | 59.21K | 15.5K | +100.00% |
| Mar 31, 2024 | SG AMERICAS SECURITIES, LLC | 0.03% | 12.24K | 63K | 12.24K | +100.00% |
| Mar 31, 2024 | CTC ALTERNATIVE STRATEGIES, LTD. | 0.03% | 11.1K | 56.94K | 11.1K | +100.00% |
| Mar 31, 2024 | ADVISOR GROUP HOLDINGS, INC. | 0.01% | 3K | 15.39K | 1K | +50.00% |
| Mar 31, 2024 | TANG CAPITAL MANAGEMENT LLC | 7.21% | 3.06M | 15.7M | -607.6K | -16.57% |
| Mar 31, 2024 | POINT72 ASSET MANAGEMENT, L.P. | 7.94% | 3.37M | 17.28M | 3.37M | +100.00% |
| Mar 31, 2024 | FARALLON CAPITAL MANAGEMENT LLC | 9.16% | 3.89M | 19.94M | 3.89M | +100.00% |
| Mar 31, 2024 | BANK OF MONTREAL /CAN/ | 0.05% | 22.6K | 115.94K | 22.6K | +100.00% |
| Mar 31, 2024 | QUBE RESEARCH & TECHNOLOGIES LTD | 0.34% | 142.73K | 732.18K | 142.73K | +100.00% |
| Mar 31, 2024 | IKARIAN CAPITAL, LLC | 0.35% | 148.09K | 759.7K | -1.02M | -87.36% |
| Mar 31, 2024 | BLACKROCK INC. | 0.41% | 171.9K | 881.85K | 91.23K | +113.08% |
| Mar 31, 2024 | SCHONFELD STRATEGIC ADVISORS LLC | 0.42% | 176.43K | 905.09K | 162.33K | +1,151.28% |
| Mar 31, 2024 | BANK OF AMERICA CORP /DE/ | 0.58% | 245.33K | 1.26M | 90.86K | +58.82% |
| Mar 31, 2024 | GHOST TREE CAPITAL, LLC | 0.59% | 250K | 1.28M | 250K | +100.00% |
| Mar 31, 2024 | GEODE CAPITAL MANAGEMENT, LLC | 0.82% | 348.43K | 1.79M | 118.3K | +51.40% |
| Mar 31, 2024 | EXOME ASSET MANAGEMENT LLC | 0.87% | 369.32K | 1.89M | 369.32K | +100.00% |
| Mar 31, 2024 | SPHERA FUNDS MANAGEMENT LTD. | 1.01% | 430K | 2.21M | -470K | -52.22% |
| Mar 31, 2024 | GOLDMAN SACHS GROUP INC | 1.3% | 551.08K | 2.83M | 551.08K | +100.00% |
| Mar 31, 2024 | MILLENNIUM MANAGEMENT LLC | 1.58% | 668.57K | 3.43M | -2.32M | -77.64% |
| Mar 31, 2024 | LOGOS GLOBAL MANAGEMENT LP | 2.36% | 1M | 5.13M | 1M | +100.00% |
| Mar 31, 2024 | PALO ALTO INVESTORS LP | 3.17% | 1.35M | 6.91M | 1.35M | +100.00% |
| Mar 31, 2024 | HUDSON BAY CAPITAL MANAGEMENT LP | 3.56% | 1.51M | 7.75M | 964.61K | +176.57% |
| Mar 31, 2024 | CITADEL ADVISORS LLC | 3.7% | 1.57M | 8.05M | 978.08K | +165.36% |
| Mar 31, 2024 | BVF INC/IL | 5.45% | 2.31M | 11.86M | 0 | 0 |
| Mar 31, 2024 | DARWIN GLOBAL MANAGEMENT, LTD. | 5.5% | 2.33M | 11.97M | 2.33M | +100.00% |
| Mar 31, 2024 | BRAIDWELL LP | 5.61% | 2.38M | 12.2M | 2.38M | +100.00% |
| Dec 31, 2023 | TWO SIGMA SECURITIES, LLC | 0% | 0 | - | -23.78K | -100.00% |
| Dec 31, 2023 | MILLENNIUM MANAGEMENT LLC | 7.05% | 2.99M | 1.61M | -41.94K | -1.38% |
| Dec 31, 2023 | VENBIO PARTNERS LLC | 6.87% | 2.91M | 1.56M | 0 | 0 |
| Dec 31, 2023 | AISLING CAPITAL MANAGEMENT LP | 6.69% | 2.83M | 1.52M | 0 | 0 |
| Dec 31, 2023 | QIMING U.S. VENTURES MANAGEMENT, LLC | 5.59% | 2.37M | 1.27M | 0 | 0 |
| Dec 31, 2023 | BVF INC/IL | 5.45% | 2.31M | 1.24M | 0 | 0 |
| Dec 31, 2023 | ORBIMED ADVISORS LLC | 3.54% | 1.5M | 805.5K | 0 | 0 |
| Dec 31, 2023 | IKARIAN CAPITAL, LLC | 2.76% | 1.17M | 629.33K | 0 | 0 |
| Dec 31, 2023 | VANGUARD GROUP INC | 2.76% | 1.17M | 628.96K | 101.44K | +9.48% |
| Dec 31, 2023 | SPHERA FUNDS MANAGEMENT LTD. | 2.12% | 900K | 483.3K | 0 | 0 |
| Dec 31, 2023 | CITADEL ADVISORS LLC | 1.39% | 591.48K | 317.63K | -248.72K | -29.60% |
| Dec 31, 2023 | HUDSON BAY CAPITAL MANAGEMENT LP | 1.29% | 546.29K | 293.36K | 0 | 0 |
| Dec 31, 2023 | VELAN CAPITAL INVESTMENT MANAGEMENT LP | 1.17% | 497.3K | 267.05K | 0 | 0 |
| Dec 31, 2023 | DAFNA CAPITAL MANAGEMENT LLC | 1.06% | 450K | 241.65K | 0 | 0 |
| Dec 31, 2023 | RENAISSANCE TECHNOLOGIES LLC | 1.04% | 441.49K | 237K | 441.49K | +100.00% |
| Dec 31, 2023 | TWO SIGMA INVESTMENTS, LP | 0.86% | 364.89K | 195.95K | -73.7K | -16.80% |
| Dec 31, 2023 | BOOTHBAY FUND MANAGEMENT, LLC | 0.61% | 256.72K | 137.86K | 0 | 0 |
| Dec 31, 2023 | GEODE CAPITAL MANAGEMENT, LLC | 0.54% | 230.14K | 123.63K | 0 | 0 |
| Dec 31, 2023 | BANK OF AMERICA CORP /DE/ | 0.36% | 154.47K | 82.95K | 21 | +0.01% |
| Dec 31, 2023 | UBS GROUP AG | 0.3% | 128.47K | 68.99K | 3.9K | +3.13% |
| Dec 31, 2023 | TWO SIGMA ADVISERS, LP | 0.24% | 102.7K | 55.15K | 25.9K | +33.72% |
| Dec 31, 2023 | BLACKROCK INC. | 0.19% | 80.68K | 43.32K | 43.25K | +115.56% |
| Dec 31, 2023 | ANNANDALE CAPITAL, LLC | 0.12% | 50K | 27K | 0 | 0 |
| Dec 31, 2023 | NORTHERN TRUST CORP | 0.11% | 44.53K | 23.92K | 0 | 0 |
| Dec 31, 2023 | STATE STREET CORP | 0.1% | 42.1K | 22.61K | 0 | 0 |
| Dec 31, 2023 | TOWER RESEARCH CAPITAL LLC (TRC) | 0.04% | 15.03K | 8.07K | -786 | -4.97% |
| Dec 31, 2023 | SCHONFELD STRATEGIC ADVISORS LLC | 0.03% | 14.1K | 7.57K | -3.1K | -18.02% |
| Dec 31, 2023 | MORGAN STANLEY | 0.01% | 3.43K | 1.84K | 0 | 0 |
| Dec 31, 2023 | ADVISOR GROUP HOLDINGS, INC. | 0% | 2K | 1.07K | 0 | 0 |
| Dec 31, 2023 | JPMORGAN CHASE & CO | 0% | 241 | 129 | -9.73K | -97.58% |
| Dec 31, 2023 | WELLS FARGO & COMPANY/MN | 0% | 241 | 129 | 12 | +5.24% |
| Dec 31, 2023 | BARCLAYS PLC | 0% | 0 | - | -18.35K | -100.00% |
| Dec 31, 2023 | CITIGROUP INC | 0% | 0 | - | -18.35K | -100.00% |
| Dec 31, 2023 | GOLDMAN SACHS GROUP INC | 0% | 0 | - | -55.88K | -100.00% |
| Dec 31, 2023 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0% | 0 | - | -56.5K | -100.00% |
| Dec 31, 2023 | CAXTON CORP | 0% | 0 | - | -21.81K | -100.00% |
| Dec 31, 2023 | TANG CAPITAL MANAGEMENT LLC | 8.65% | 3.67M | 1.97M | -332.4K | -8.31% |
| Dec 31, 2023 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0% | 0 | - | -11K | -100.00% |
| Dec 31, 2023 | ARMISTICE CAPITAL, LLC | 0% | 0 | - | -750K | -100.00% |
| Dec 31, 2023 | EXODUSPOINT CAPITAL MANAGEMENT, LP | 0% | 0 | - | -999.55K | -100.00% |
| Dec 31, 2023 | WALLEYE CAPITAL LLC | 0% | 0 | - | -148.89K | -100.00% |
| Sep 30, 2023 | SAMSARA BIOCAPITAL, LLC | 0% | 0 | - | -830.57K | -100.00% |
| Sep 30, 2023 | POINT72 ASSET MANAGEMENT, L.P. | 0% | 0 | - | -400K | -100.00% |
| Sep 30, 2023 | J. GOLDMAN & CO LP | 0% | 0 | - | -13.5K | -100.00% |
| Sep 30, 2023 | MEITAV INVESTMENT HOUSE LTD | 0% | 0 | - | -2.01K | -100.00% |
| Sep 30, 2023 | RENAISSANCE TECHNOLOGIES LLC | 0% | 0 | - | -16.8K | -100.00% |
| Sep 30, 2023 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 0% | 0 | - | -1.38M | -100.00% |
| Sep 30, 2023 | ROYAL BANK OF CANADA | 0% | 0 | - | -359 | -100.00% |
| Sep 30, 2023 | WELLS FARGO & COMPANY/MN | 0% | 229 | 152 | 131 | +133.67% |
| Sep 30, 2023 | ADVISOR GROUP HOLDINGS, INC. | 0.01% | 2K | 1.33K | 2K | +100.00% |
| Sep 30, 2023 | MORGAN STANLEY | 0.01% | 3.43K | 2.27K | 0 | 0 |
| Sep 30, 2023 | JPMORGAN CHASE & CO | 0.04% | 9.98K | 6.61K | -5.16K | -34.10% |
| Sep 30, 2023 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0.04% | 11K | 7.29K | 11K | +100.00% |
| Sep 30, 2023 | TOWER RESEARCH CAPITAL LLC (TRC) | 0.06% | 15.82K | 10.49K | 15.72K | +15,716.00% |
| Sep 30, 2023 | SCHONFELD STRATEGIC ADVISORS LLC | 0.06% | 17.2K | 11.4K | -116.9K | -87.17% |
| Sep 30, 2023 | BARCLAYS PLC | 0.07% | 18.35K | 12K | 18.35K | +100.00% |
| Sep 30, 2023 | CITIGROUP INC | 0.07% | 18.35K | 12.16K | 18.35K | +100.00% |
| Sep 30, 2023 | CAXTON CORP | 0.08% | 21.81K | 14.45K | 88 | +0.41% |
| Sep 30, 2023 | TWO SIGMA SECURITIES, LLC | 0.09% | 23.78K | 15.75K | 23.78K | +100.00% |
| Sep 30, 2023 | BLACKROCK INC. | 0.14% | 37.43K | 24.8K | -3.98K | -9.61% |
| Sep 30, 2023 | STATE STREET CORP | 0.15% | 42.1K | 27.9K | 0 | 0 |
| Sep 30, 2023 | NORTHERN TRUST CORP | 0.16% | 44.53K | 29.51K | 29.54K | +197.07% |
| Sep 30, 2023 | ANNANDALE CAPITAL, LLC | 0.18% | 50K | 33K | 0 | 0 |
| Sep 30, 2023 | GOLDMAN SACHS GROUP INC | 0.2% | 55.88K | 37.03K | 55.88K | +100.00% |
| Sep 30, 2023 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0.2% | 56.5K | 37.44K | 0 | 0 |
| Sep 30, 2023 | TWO SIGMA ADVISERS, LP | 0.28% | 76.8K | 50.89K | 76.8K | +100.00% |
| Sep 30, 2023 | UBS GROUP AG | 0.45% | 124.56K | 82.58K | 108.48K | +674.73% |
| Sep 30, 2023 | WALLEYE CAPITAL LLC | 0.54% | 148.89K | 98.65K | 45.26K | +43.67% |
| Sep 30, 2023 | BANK OF AMERICA CORP /DE/ | 0.56% | 154.45K | 102.25K | 154.45K | +15,444,700.00% |
| Sep 30, 2023 | GEODE CAPITAL MANAGEMENT, LLC | 0.83% | 230.14K | 152.55K | 93.97K | +69.01% |
| Sep 30, 2023 | BOOTHBAY FUND MANAGEMENT, LLC | 0.93% | 256.72K | 170.1K | 22.45K | +9.58% |
| Sep 30, 2023 | TWO SIGMA INVESTMENTS, LP | 1.59% | 438.59K | 290.61K | 14.69K | +3.47% |
| Sep 30, 2023 | DAFNA CAPITAL MANAGEMENT LLC | 1.63% | 450K | 298.17K | 0 | 0 |
| Sep 30, 2023 | VELAN CAPITAL INVESTMENT MANAGEMENT LP | 1.8% | 497.3K | 329.51K | 0 | 0 |
| Sep 30, 2023 | HUDSON BAY CAPITAL MANAGEMENT LP | 1.98% | 546.29K | 361.97K | 0 | 0 |
| Sep 30, 2023 | ARMISTICE CAPITAL, LLC | 2.72% | 750K | 496.95K | -1.65M | -68.70% |
| Sep 30, 2023 | CITADEL ADVISORS LLC | 3.05% | 840.2K | 556.72K | 1.61K | +0.19% |
| Sep 30, 2023 | SPHERA FUNDS MANAGEMENT LTD. | 3.26% | 900K | 596.34K | 0 | 0 |
| Sep 30, 2023 | EXODUSPOINT CAPITAL MANAGEMENT, LP | 3.62% | 999.55K | 662K | -499.77K | -33.33% |
| Sep 30, 2023 | VANGUARD GROUP INC | 3.88% | 1.07M | 708.85K | -5.35K | -0.50% |
| Sep 30, 2023 | IKARIAN CAPITAL, LLC | 4.25% | 1.17M | 776.53K | 22.45K | +1.95% |
| Sep 30, 2023 | ORBIMED ADVISORS LLC | 5.44% | 1.5M | 993.9K | 0 | 0 |
| Sep 30, 2023 | BVF INC/IL | 8.39% | 2.31M | 1.53M | 0 | 0 |
| Sep 30, 2023 | QIMING U.S. VENTURES MANAGEMENT, LLC | 8.6% | 2.37M | 1.57M | 0 | 0 |
| Sep 30, 2023 | AISLING CAPITAL MANAGEMENT LP | 10.28% | 2.83M | 1.88M | 0 | 0 |
| Sep 30, 2023 | VENBIO PARTNERS LLC | 10.57% | 2.91M | 1.93M | 0 | 0 |
| Sep 30, 2023 | MILLENNIUM MANAGEMENT LLC | 11% | 3.03M | 2.01M | 715.79K | +30.90% |
| Sep 30, 2023 | TANG CAPITAL MANAGEMENT LLC | 14.51% | 4M | 2.65M | 0 | 0 |
