| 2024-03-31 | CITADEL ADVISORS LLC | 0.17% | 986.11K | 3.25M | 342.95K | +53.32% |
| 2024-03-31 | ROSALIND ADVISORS, INC. | 0.03% | 200K | 660K | 0 | 0 |
| 2024-03-31 | MILLENNIUM MANAGEMENT LLC | 1.23% | 7.3M | 24.1M | -7.43M | -50.43% |
| 2024-03-31 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.19% | 7.2M | 23.76M | 7.2M | +100.00% |
| 2024-03-31 | FAIRMOUNT FUNDS MANAGEMENT LLC | 1.1% | 6.67M | 22M | 6.67M | +100.00% |
| 2024-03-31 | BOXER CAPITAL, LLC | 0.99% | 6M | 19.8M | 3M | +100.00% |
| 2024-03-31 | INVESCO LTD. | 0.92% | 5.47M | 18.05M | 1.11M | +25.43% |
| 2024-03-31 | NORTHERN TRUST CORP | 0.85% | 5.03M | 16.59M | -89.17K | -1.74% |
| 2024-03-31 | GOLDMAN SACHS GROUP INC | 0.74% | 4.39M | 14.49M | 1.21M | +38.05% |
| 2024-03-31 | MORGAN STANLEY | 0.56% | 3.35M | 11.07M | -7.21M | -68.25% |
| 2024-03-31 | SAMLYN CAPITAL, LLC | 0.52% | 3.11M | 10.28M | 3.11M | +100.00% |
| 2024-03-31 | BLACKROCK INC. | 6.96% | 41.41M | 136.67M | -758.1K | -1.80% |
| 2024-03-31 | DEEP TRACK CAPITAL, LP | 5.05% | 30.51M | 100.67M | 922.48K | +3.12% |
| 2024-03-31 | VANGUARD GROUP INC | 5.02% | 29.87M | 98.57M | 1.3M | +4.57% |
| 2024-03-31 | VIVO CAPITAL, LLC | 4.51% | 27.23M | 89.84M | 3.08M | +12.76% |
| 2024-03-31 | TCG CROSSOVER MANAGEMENT, LLC | 2.88% | 17.39M | 57.39M | -5.98M | -25.60% |
| 2024-03-31 | FMR LLC | 2.14% | 12.76M | 42.11M | 5.73M | +81.45% |
| 2024-03-31 | ORBIMED ADVISORS LLC | 2.14% | 12.89M | 42.55M | 12.41M | +2,558.48% |
| 2024-03-31 | RA CAPITAL MANAGEMENT, L.P. | 7.66% | 46.2M | 152.47M | 0 | 0 |
| 2024-03-31 | NEA MANAGEMENT COMPANY, LLC | 2.12% | 12.78M | 42.16M | -10M | -43.91% |
| 2024-03-31 | GEODE CAPITAL MANAGEMENT, LLC | 1.92% | 11.43M | 37.71M | 482.34K | +4.41% |
| 2024-03-31 | WELLINGTON MANAGEMENT GROUP LLP | 1.84% | 10.94M | 36.11M | 1.46M | +15.37% |
| 2024-03-31 | BIOIMPACT CAPITAL LLC | 1.74% | 10.48M | 34.57M | -239.95K | -2.24% |
| 2024-03-31 | LOGOS GLOBAL MANAGEMENT LP | 1.49% | 9M | 29.7M | 9M | +100.00% |
| 2024-03-31 | SEGALL BRYANT & HAMILL, LLC | 0.74% | 4.45M | 14.68M | 29.08K | +0.66% |
| 2024-03-31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.65% | 3.89M | 12.84M | 47.26K | +1.23% |
| 2024-03-31 | DEUTSCHE BANK AG\ | 0.23% | 1.35M | 4.46M | -5.72M | -80.87% |
| 2024-03-31 | BRIDGER MANAGEMENT, LLC | 0.22% | 1.34M | 4.42M | 1.34M | +100.00% |
| 2024-03-31 | NAN FUNG GROUP HOLDINGS LTD | 0.22% | 1.32M | 4.37M | 411K | +44.99% |
| 2024-03-31 | ARTAL GROUP S.A. | 0.21% | 1.28M | 4.23M | 1.28M | +100.00% |
| 2024-03-31 | WOODLINE PARTNERS LP | 0.2% | 1.21M | 4.01M | 1.21M | +100.00% |
| 2024-03-31 | READYSTATE ASSET MANAGEMENT LP | 0.2% | 1.19M | 3.93M | 1.19M | +100.00% |
| 2024-03-31 | KENNEDY CAPITAL MANAGEMENT LLC | 0.19% | 1.13M | 3.71M | -9.92K | -0.87% |
| 2024-03-31 | SATURN V CAPITAL MANAGEMENT LLC | 0.19% | 1.12M | 3.71M | 1.12M | +100.00% |
| 2024-03-31 | STATE STREET CORP | 5.31% | 31.6M | 104.29M | 5.98M | +23.33% |
| 2024-03-31 | FARALLON CAPITAL MANAGEMENT LLC | 1.24% | 7.5M | 24.73M | 7.5M | +100.00% |
| 2024-03-31 | BALYASNY ASSET MANAGEMENT L.P. | 0.52% | 3.14M | 10.36M | 3.14M | +100.00% |
| 2024-03-31 | ALLY BRIDGE GROUP (NY) LLC | 0.46% | 2.76M | 9.11M | -211.14K | -7.11% |
| 2024-03-31 | AFFINITY ASSET ADVISORS, LLC | 0.41% | 2.5M | 8.25M | 2.5M | +100.00% |
| 2024-03-31 | RAFFERTY ASSET MANAGEMENT, LLC | 0.4% | 2.41M | 7.96M | 742.12K | +44.46% |
| 2024-03-31 | VESTAL POINT CAPITAL, LP | 0.36% | 2.2M | 7.26M | 2.2M | +100.00% |
| 2024-03-31 | CITIGROUP INC | 0.36% | 2.15M | 7.1M | 1.44M | +202.12% |
| 2024-03-31 | PRICE T ROWE ASSOCIATES INC /MD/ | 0.35% | 2.06M | 6.82M | 1.88M | +999.68% |
| 2024-03-31 | JPMORGAN CHASE & CO | 0.34% | 2M | 6.6M | 261.14K | +15.02% |
| 2024-03-31 | UBS GROUP AG | 0.3% | 1.81M | 5.96M | 365.71K | +25.37% |
| 2024-03-31 | RUSSELL INVESTMENTS GROUP, LTD. | 0.29% | 1.75M | 5.78M | 513.37K | +41.49% |
| 2024-03-31 | LAURION CAPITAL MANAGEMENT LP | 0.28% | 1.67M | 5.5M | 1.67M | +100.00% |
| 2024-03-31 | BANK OF NEW YORK MELLON CORP | 0.27% | 1.6M | 5.28M | -170.41K | -9.62% |
| 2024-03-31 | ALTITUDE CREST PARTNERS INC. | 0.25% | 1.53M | 5.05M | 1.53M | +100.00% |
| 2024-03-31 | NUVEEN ASSET MANAGEMENT, LLC | 0.25% | 1.5M | 4.95M | 10.41K | +0.70% |
| 2024-03-31 | MML INVESTORS SERVICES, LLC | 0.17% | 1.05M | 3.48M | -241.8K | -18.67% |
| 2024-03-31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.08% | 481.71K | 1.59M | 481.71K | +100.00% |
| 2024-03-31 | SWISS NATIONAL BANK | 0.14% | 804.3K | 2.65M | 30.7K | +3.97% |
| 2024-03-31 | RHUMBLINE ADVISERS | 0.12% | 727.22K | 2.4M | 18.08K | +2.55% |
| 2024-03-31 | CREDIT SUISSE AG/ | 0.12% | 686.89K | 2.27M | 17.76K | +2.65% |
| 2024-03-31 | PATHWAY CAPITAL MANAGEMENT, LP | 0.11% | 636.84K | 2.1M | 636.84K | +100.00% |
| 2024-03-31 | ALLIANCEBERNSTEIN L.P. | 0.09% | 512.74K | 1.69M | 0 | 0 |
| 2024-03-31 | VELAN CAPITAL INVESTMENT MANAGEMENT LP | 0.08% | 500K | 1.65M | -278.5K | -35.77% |
| 2024-03-31 | LEGAL & GENERAL GROUP PLC | 0.07% | 396.05K | 1.31B | -14.37K | -3.50% |
| 2024-03-31 | ALPS ADVISORS INC | 0.06% | 385.15K | 1.27M | 26.37K | +7.35% |
| 2024-03-31 | SUMMIT X, LLC | 0.06% | 381.67K | 1.26M | 19.71K | +5.45% |
| 2024-03-31 | PROFUND ADVISORS LLC | 0.06% | 376.36K | 1.24B | 100.54K | +36.45% |
| 2024-03-31 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0.06% | 362.87K | 1.2M | 102.04K | +39.12% |
| 2024-03-31 | ALLSPRING GLOBAL INVESTMENTS HOLDINGS, LLC | 0.06% | 344.06K | 1.14M | -6.96K | -1.98% |
| 2024-03-31 | STATE OF WISCONSIN INVESTMENT BOARD | 0.06% | 331.81K | 1.09M | -40.84K | -10.96% |
| 2024-03-31 | BNP PARIBAS ARBITRAGE, SNC | 0.05% | 295.55K | 975.32K | -418.46K | -58.61% |
| 2024-03-31 | STATE OF TENNESSEE, TREASURY DEPARTMENT | 0.05% | 279.93K | 923.77K | 279.93K | +100.00% |
| 2024-03-31 | METLIFE INVESTMENT MANAGEMENT, LLC | 0.05% | 271.57K | 896.19K | 8.91K | +3.39% |
| 2024-03-31 | ADVISOR GROUP HOLDINGS, INC. | 0.05% | 268.2K | 885.07K | 41K | +18.04% |
| 2024-03-31 | AMERICAN INTERNATIONAL GROUP, INC. | 0.04% | 252.5K | 833.23K | -2.17K | -0.85% |
| 2024-03-31 | COMMONWEALTH EQUITY SERVICES, LLC | 0.04% | 251.72K | 831K | 251.72K | +100.00% |
| 2024-03-31 | SILVERARC CAPITAL MANAGEMENT, LLC | 0.04% | 250K | 825K | 250K | +100.00% |
| 2024-03-31 | TD ASSET MANAGEMENT INC | 0.04% | 238.8K | 788.04M | 238.8K | +100.00% |
| 2024-03-31 | WELLS FARGO & COMPANY/MN | 0.04% | 209.37K | 690.93K | 29.57K | +16.44% |
| 2023-12-31 | NUVEEN ASSET MANAGEMENT, LLC | 0.26% | 1.49M | 3.15M | 24.85K | +1.70% |
| 2023-12-31 | UBS GROUP AG | 0.25% | 1.44M | 3.04M | 790.42K | +121.38% |
| 2023-12-31 | MML INVESTORS SERVICES, LLC | 0.22% | 1.3M | 2.73M | 0 | 0 |
| 2023-12-31 | WALLEYE CAPITAL LLC | 0.22% | 1.28M | 2.69M | -950.55K | -42.70% |
| 2023-12-31 | RUSSELL INVESTMENTS GROUP, LTD. | 0.21% | 1.24M | 2.61M | 204.77K | +19.83% |
| 2023-12-31 | KENNEDY CAPITAL MANAGEMENT LLC | 0.2% | 1.14M | 2.4M | 1.14M | +100.00% |
| 2023-12-31 | NAN FUNG GROUP HOLDINGS LTD | 0.16% | 913.55K | 1.93M | 160K | +21.23% |
| 2023-12-31 | VELAN CAPITAL INVESTMENT MANAGEMENT LP | 0.13% | 778.5K | 1.64M | 0 | 0 |
| 2023-12-31 | SWISS NATIONAL BANK | 0.13% | 773.6K | 1.63M | -232.9K | -23.14% |
| 2023-12-31 | BNP PARIBAS ARBITRAGE, SNC | 0.12% | 714.01K | 1.51M | 196.33K | +37.92% |
| 2023-12-31 | CITIGROUP INC | 0.12% | 711.95K | 1.5M | -93.96K | -11.66% |
| 2023-12-31 | RHUMBLINE ADVISERS | 0.12% | 709.14K | 1.5M | 3.16K | +0.45% |
| 2023-12-31 | CRESTLINE MANAGEMENT, LP | 0.12% | 687.38K | 1.45M | 102.23K | +17.47% |
| 2023-12-31 | CREDIT SUISSE AG/ | 0.12% | 669.13K | 1.41M | 12.56K | +1.91% |
| 2023-12-31 | CITADEL ADVISORS LLC | 0.11% | 643.16K | 1.36M | 251.46K | +64.19% |
| 2023-12-31 | AMERIPRISE FINANCIAL INC | 0.11% | 617.36K | 1.3M | 13.26K | +2.20% |
| 2023-12-31 | JANE STREET GROUP, LLC | 0.11% | 613.42K | 1.29M | 425.06K | +225.67% |
| 2023-12-31 | | 0.1% | 607.5K | 1.28M | 607.5K | +100.00% |
| 2023-12-31 | BANK OF AMERICA CORP /DE/ | 0.09% | 546.8K | 1.15M | -657.27K | -54.59% |
| 2023-12-31 | ALLIANCEBERNSTEIN L.P. | 0.09% | 512.74K | 1.08M | 0 | 0 |
| 2023-12-31 | ORBIMED ADVISORS LLC | 0.08% | 485K | 1.02M | 485K | +100.00% |
| 2023-12-31 | RA CAPITAL MANAGEMENT, L.P. | 7.97% | 46.2M | 97.49M | 0 | 0 |
| 2023-12-31 | BLACKROCK INC. | 7.28% | 42.17M | 88.98M | 5.01M | +13.49% |
| 2023-12-31 | DEEP TRACK CAPITAL, LP | 5.1% | 29.58M | 62.42M | 3.88M | +15.11% |
| 2023-12-31 | VANGUARD GROUP INC | 4.93% | 28.56M | 60.27M | 1.91M | +7.18% |
| 2023-12-31 | STATE STREET CORP | 4.42% | 25.63M | 54.07M | 254.22K | +1.00% |
| 2023-12-31 | VIVO CAPITAL, LLC | 4.17% | 24.14M | 50.94M | 7.62M | +46.11% |
| 2023-12-31 | TCG CROSSOVER MANAGEMENT, LLC | 4.03% | 23.38M | 49.32M | 0 | 0 |
| 2023-12-31 | NEA MANAGEMENT COMPANY, LLC | 3.93% | 22.78M | 48.06M | 0 | 0 |
| 2023-12-31 | MILLENNIUM MANAGEMENT LLC | 2.54% | 14.73M | 31.08M | -1.34M | -8.35% |
| 2023-12-31 | GEODE CAPITAL MANAGEMENT, LLC | 1.89% | 10.94M | 23.09M | 930.75K | +9.30% |
| 2023-12-31 | BIOIMPACT CAPITAL LLC | 1.85% | 10.72M | 22.61M | 3.14K | +0.03% |
| 2023-12-31 | MORGAN STANLEY | 1.82% | 10.56M | 22.29M | 9.2M | +673.92% |
| 2023-12-31 | WELLINGTON MANAGEMENT GROUP LLP | 1.64% | 9.48M | 20.01M | 9.48M | +100.00% |
| 2023-12-31 | SOFINNOVA INVESTMENTS, INC. | 1.52% | 8.81M | 18.6M | 5.11M | +138.07% |
| 2023-12-31 | DEUTSCHE BANK AG\ | 1.22% | 7.07M | 14.91M | 6.82M | +2,763.48% |
| 2023-12-31 | FMR LLC | 1.21% | 7.03M | 14.84M | -528.71K | -6.99% |
| 2023-12-31 | NORTHERN TRUST CORP | 0.88% | 5.12M | 10.8M | -241.3K | -4.50% |
| 2023-12-31 | SEGALL BRYANT & HAMILL, LLC | 0.76% | 4.42M | 9.33M | -570.68K | -11.44% |
| 2023-12-31 | INVESCO LTD. | 0.75% | 4.36M | 9.2M | -197.46K | -4.33% |
| 2023-12-31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.66% | 3.84M | 8.11M | 208.17K | +5.73% |
| 2023-12-31 | ARMISTICE CAPITAL, LLC | 0.57% | 3.3M | 6.95M | -328K | -9.05% |
| 2023-12-31 | GOLDMAN SACHS GROUP INC | 0.55% | 3.18M | 6.71M | -339.06K | -9.63% |
| 2023-12-31 | BOXER CAPITAL, LLC | 0.52% | 3M | 6.33M | 0 | 0 |
| 2023-12-31 | ALLY BRIDGE GROUP (NY) LLC | 0.51% | 2.97M | 6.27M | 750K | +33.76% |
| 2023-12-31 | MARSHALL WACE, LLP | 0.36% | 2.08M | 4.39M | -3.78M | -64.53% |
| 2023-12-31 | BANK OF NEW YORK MELLON CORP | 0.31% | 1.77M | 3.74M | 157.89K | +9.79% |
| 2023-12-31 | JPMORGAN CHASE & CO | 0.3% | 1.74M | 3.67M | 109.39K | +6.71% |
| 2023-12-31 | RAFFERTY ASSET MANAGEMENT, LLC | 0.29% | 1.67M | 3.52M | -233.18K | -12.26% |
| 2023-12-31 | BARCLAYS PLC | 0.27% | 1.58M | 3.33M | 11.24K | +0.72% |
