| 2024-03-31 | ASSENAGON ASSET MANAGEMENT S.A. | 0.17% | 71.38K | 2.51M | -26.04K | -26.73% |
| 2024-03-31 | VICTORY CAPITAL MANAGEMENT INC | 0.07% | 29.1K | 1.02M | 15.47K | +113.50% |
| 2024-03-31 | INVESCO LTD. | 0.05% | 22.97K | 808.47K | -3.02K | -11.63% |
| 2024-03-31 | SEVEN EIGHT CAPITAL, LP | 0.05% | 22.84K | 803.79K | 22.84K | +100.00% |
| 2024-03-31 | STATE OF WISCONSIN INVESTMENT BOARD | 0.05% | 20.1K | 707.45K | -2.49K | -11.02% |
| 2024-03-31 | METLIFE INVESTMENT MANAGEMENT, LLC | 0.05% | 19.41K | 683.3K | 0 | 0 |
| 2024-03-31 | MIRAE ASSET GLOBAL INVESTMENTS CO., LTD. | 0.05% | 19.29K | 703.65K | -4.47K | -18.81% |
| 2024-03-31 | AMERICAN INTERNATIONAL GROUP, INC. | 0.04% | 18.8K | 661.65K | 533 | +2.92% |
| 2024-03-31 | ALGERT GLOBAL LLC | 0.04% | 16.58K | 584K | 0 | 0 |
| 2024-03-31 | NEW YORK STATE COMMON RETIREMENT FUND | 0.04% | 16.42K | 578K | 61 | +0.37% |
| 2024-03-31 | HEALTHINVEST PARTNERS AB | 0.04% | 14.95K | 526.31K | 0 | 0 |
| 2024-03-31 | PRICE T ROWE ASSOCIATES INC /MD/ | 5.95% | 2.52M | 88.83M | 300.96K | +13.54% |
| 2024-03-31 | ECOR1 CAPITAL, LLC | 5.62% | 2.38M | 83.93M | 2.17M | +1,028.64% |
| 2024-03-31 | VANGUARD GROUP INC | 5.33% | 2.26M | 79.59M | -59.85K | -2.58% |
| 2024-03-31 | ARTAL GROUP S.A. | 5.22% | 2.21M | 77.9M | 75K | +3.51% |
| 2024-03-31 | PICTET ASSET MANAGEMENT HOLDING SA | 2.8% | 1.19M | 41.78M | -603.93K | -33.72% |
| 2024-03-31 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.14% | 483.97K | 17.04M | -16.07K | -3.21% |
| 2024-03-31 | TWO SIGMA ADVISERS, LP | 0.91% | 385.1K | 13.56M | -170K | -30.63% |
| 2024-03-31 | NORTHERN TRUST CORP | 0.8% | 339.31K | 11.94M | -4.61K | -1.34% |
| 2024-03-31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.77% | 326.7K | 11.5M | 7.25K | +2.27% |
| 2024-03-31 | BIOIMPACT CAPITAL LLC | 0.77% | 325.33K | 11.45M | 1.59K | +0.49% |
| 2024-03-31 | PERCEPTIVE ADVISORS LLC | 0.68% | 288.22K | 10.15M | 231.24K | +405.83% |
| 2024-03-31 | TWO SIGMA INVESTMENTS, LP | 0.61% | 256.75K | 9.04M | -220.12K | -46.16% |
| 2024-03-31 | CANDRIAM S.C.A. | 0.59% | 249.93K | 8.8M | 0 | 0 |
| 2024-03-31 | D. E. SHAW & CO., INC. | 0.51% | 214.46K | 7.55M | -87.45K | -28.96% |
| 2024-03-31 | FIDUCIARY TRUST CO | 0.51% | 214.37K | 7.55M | 0 | 0 |
| 2024-03-31 | CITIGROUP INC | 0.45% | 190.35K | 6.7M | 103.01K | +117.95% |
| 2024-03-31 | OMEGA FUND MANAGEMENT, LLC | 0.38% | 159.85K | 5.63M | -150K | -48.41% |
| 2024-03-31 | BALYASNY ASSET MANAGEMENT L.P. | 0.35% | 149.25K | 5.25M | 131.52K | +741.72% |
| 2024-03-31 | UBS GROUP AG | 0.35% | 148.99K | 5.24M | 56.44K | +60.98% |
| 2024-03-31 | ENSIGN PEAK ADVISORS, INC | 0.33% | 141.22K | 4.97M | -88.7K | -38.58% |
| 2024-03-31 | NUVEEN ASSET MANAGEMENT, LLC | 0.3% | 126.7K | 4.46M | 310 | +0.25% |
| 2024-03-31 | TD ASSET MANAGEMENT INC | 0.3% | 125.9K | 4.43M | 37.18K | +41.91% |
| 2024-03-31 | BANK OF NEW YORK MELLON CORP | 0.29% | 124.89K | 4.4M | -4.74K | -3.66% |
| 2024-03-31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.28% | 118.9K | 4.19M | 106K | +821.71% |
| 2024-03-31 | STATE STREET CORP | 6.29% | 2.67M | 93.83M | 101.45K | +3.96% |
| 2024-03-31 | FEDERATED HERMES, INC. | 2.35% | 995K | 35.02M | -5K | -0.50% |
| 2024-03-31 | GEODE CAPITAL MANAGEMENT, LLC | 2.11% | 895.2K | 31.52M | 42.16K | +4.94% |
| 2024-03-31 | CITADEL ADVISORS LLC | 2.05% | 866.9K | 30.51M | 763.36K | +737.28% |
| 2024-03-31 | RAFFERTY ASSET MANAGEMENT, LLC | 0.52% | 220.79K | 7.77M | 18.07K | +8.91% |
| 2024-03-31 | MORGAN STANLEY | 0.52% | 220.58K | 7.76M | -475.35K | -68.30% |
| 2024-03-31 | T. ROWE PRICE INVESTMENT MANAGEMENT, INC. | 0.46% | 196.23K | 6.91M | 32.88K | +20.13% |
| 2024-03-31 | BANK OF AMERICA CORP /DE/ | 0.27% | 114.56K | 4.03M | -169.75K | -59.71% |
| 2024-03-31 | PRUDENTIAL FINANCIAL INC | 0.27% | 113.63K | 4M | -77.92K | -40.68% |
| 2024-03-31 | ALLIANCEBERNSTEIN L.P. | 0.26% | 111.78K | 3.93M | -97.39K | -46.56% |
| 2024-03-31 | CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD. | 0.25% | 104.63K | 3.68M | 70.76K | +208.94% |
| 2024-03-31 | WOODLINE PARTNERS LP | 0.24% | 100K | 3.52M | 100K | +100.00% |
| 2024-03-31 | ALLIANZ ASSET MANAGEMENT GMBH | 0.22% | 93.67K | 3.3M | 10.18K | +12.20% |
| 2024-03-31 | ATOM INVESTORS LP | 0.2% | 86.63K | 3.05M | 12.92K | +17.53% |
| 2024-03-31 | SATURN V CAPITAL MANAGEMENT LLC | 0.2% | 85.63K | 3.01M | -126.71K | -59.67% |
| 2024-03-31 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0.19% | 81.95K | 2.88M | 21.97K | +36.64% |
| 2024-03-31 | FMR LLC | 17.71% | 7.51M | 264.2M | 722.28K | +10.65% |
| 2024-03-31 | POINT72 ASSET MANAGEMENT, L.P. | 11.06% | 4.69M | 164.99M | 96.1K | +2.09% |
| 2024-03-31 | WELLINGTON MANAGEMENT GROUP LLP | 9.49% | 4.02M | 141.61M | 645.67K | +19.12% |
| 2024-03-31 | BLACKROCK INC. | 7.75% | 3.28M | 115.57M | -19.36K | -0.59% |
| 2024-03-31 | ORBIMED ADVISORS LLC | 1.32% | 558.5K | 19.66M | 285.1K | +104.28% |
| 2024-03-31 | DAFNA CAPITAL MANAGEMENT LLC | 0.55% | 231.75K | 8.16M | 0 | 0 |
| 2024-03-31 | AFFINITY ASSET ADVISORS, LLC | 0.53% | 225K | 7.92M | 182.33K | +427.30% |
| 2024-03-31 | DIMENSIONAL FUND ADVISORS LP | 0.52% | 221.16K | 7.78M | -14.06K | -5.98% |
| 2024-03-31 | GOLDMAN SACHS GROUP INC | 1.28% | 543.95K | 19.15M | -91.12K | -14.35% |
| 2024-03-31 | SWISS NATIONAL BANK | 0.14% | 58.9K | 2.07M | 2.2K | +3.88% |
| 2024-03-31 | RHUMBLINE ADVISERS | 0.12% | 51.7K | 1.82M | 1.83K | +3.67% |
| 2024-03-31 | BNP PARIBAS ARBITRAGE, SNC | 0.11% | 47.02K | 1.66M | -41.33K | -46.78% |
| 2024-03-31 | JPMORGAN CHASE & CO | 0.1% | 40.78K | 1.44M | -19.57K | -32.42% |
| 2024-03-31 | BANK OF MONTREAL /CAN/ | 0.09% | 36.65K | 1.3M | 36.65K | +100.00% |
| 2024-03-31 | ALPS ADVISORS INC | 0.08% | 35.29K | 1.24M | 1.82K | +5.44% |
| 2024-03-31 | PROFUND ADVISORS LLC | 0.08% | 34.27K | 1.21B | 1.39K | +4.22% |
| 2024-03-31 | CREDIT SUISSE AG/ | 0.08% | 32.22K | 1.13M | 8.26K | +34.49% |
| 2024-03-31 | LEGAL & GENERAL GROUP PLC | 0.07% | 29.4K | 1.03B | 519 | +1.80% |
| 2023-12-31 | JENNISON ASSOCIATES LLC | 1.25% | 616.95K | 17.82M | 616.95K | +100.00% |
| 2023-12-31 | TWO SIGMA ADVISERS, LP | 1.12% | 555.1K | 16.03M | 383.9K | +224.24% |
| 2023-12-31 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.01% | 500.04K | 14.44M | -90.79K | -15.37% |
| 2023-12-31 | FINEPOINT CAPITAL LP | 1% | 496.86K | 14.35M | 171.5K | +52.71% |
| 2023-12-31 | TWO SIGMA INVESTMENTS, LP | 0.96% | 476.87K | 13.77M | 62.63K | +15.12% |
| 2023-12-31 | NORTHERN TRUST CORP | 0.69% | 343.92K | 9.93M | 22.48K | +6.99% |
| 2023-12-31 | MARSHALL WACE, LLP | 0.68% | 336.52K | 9.72M | 291.87K | +653.73% |
| 2023-12-31 | BIOIMPACT CAPITAL LLC | 0.65% | 323.74K | 9.35M | 123.74K | +61.87% |
| 2023-12-31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.64% | 319.45K | 9.23M | 15.17K | +4.99% |
| 2023-12-31 | OMEGA FUND MANAGEMENT, LLC | 0.63% | 309.85K | 8.95M | 0 | 0 |
| 2023-12-31 | D. E. SHAW & CO., INC. | 0.61% | 301.9K | 8.72M | 157.94K | +109.71% |
| 2023-12-31 | BANK OF AMERICA CORP /DE/ | 0.57% | 284.31K | 8.21M | 162.38K | +133.17% |
| 2023-12-31 | ORBIMED ADVISORS LLC | 0.55% | 273.4K | 7.9M | 64.9K | +31.13% |
| 2023-12-31 | CANDRIAM S.C.A. | 0.5% | 249.93K | 7.22M | 0 | 0 |
| 2023-12-31 | DIMENSIONAL FUND ADVISORS LP | 0.47% | 235.23K | 6.79M | -294.59K | -55.60% |
| 2023-12-31 | DAFNA CAPITAL MANAGEMENT LLC | 0.47% | 231.75K | 6.69M | 0 | 0 |
| 2023-12-31 | ENSIGN PEAK ADVISORS, INC | 0.46% | 229.92K | 6.64M | 19.63K | +9.33% |
| 2023-12-31 | FIDUCIARY TRUST CO | 0.43% | 214.37K | 6.19M | 0 | 0 |
| 2023-12-31 | SATURN V CAPITAL MANAGEMENT LLC | 0.43% | 212.34K | 6.13M | 75.6K | +55.29% |
| 2023-12-31 | ECOR1 CAPITAL, LLC | 0.43% | 211.26K | 6.1M | -1.27M | -85.73% |
| 2023-12-31 | ALLIANCEBERNSTEIN L.P. | 0.42% | 209.18K | 6.04M | 167.61K | +403.19% |
| 2023-12-31 | RAFFERTY ASSET MANAGEMENT, LLC | 0.41% | 202.73K | 5.85M | 63.63K | +45.75% |
| 2023-12-31 | LOGOS GLOBAL MANAGEMENT LP | 0.4% | 200K | 5.78M | 200K | +100.00% |
| 2023-12-31 | PRUDENTIAL FINANCIAL INC | 0.39% | 191.54K | 5.53M | 191.54K | +100.00% |
| 2023-12-31 | T. ROWE PRICE INVESTMENT MANAGEMENT, INC. | 0.33% | 163.35K | 4.72M | -466.43K | -74.06% |
| 2023-12-31 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0.32% | 158.24K | 4.57M | 48.9K | +44.73% |
| 2023-12-31 | DRIEHAUS CAPITAL MANAGEMENT LLC | 0.28% | 136.47K | 3.94M | -2.66K | -1.91% |
| 2023-12-31 | BARCLAYS PLC | 0.26% | 130.39K | 3.77M | 56.39K | +76.20% |
| 2023-12-31 | BANK OF NEW YORK MELLON CORP | 0.26% | 129.64K | 3.74M | 5.71K | +4.61% |
| 2023-12-31 | NUVEEN ASSET MANAGEMENT, LLC | 0.26% | 126.39K | 3.65M | 14.29K | +12.75% |
| 2023-12-31 | TWINBEECH CAPITAL LP | 0.25% | 123.09K | 3.55M | 3.31K | +2.77% |
| 2023-12-31 | CITADEL ADVISORS LLC | 0.21% | 103.54K | 2.99M | -417.81K | -80.14% |
| 2023-12-31 | JANE STREET GROUP, LLC | 0.21% | 101.89K | 2.94M | -8.16K | -7.41% |
| 2023-12-31 | ASSENAGON ASSET MANAGEMENT S.A. | 0.2% | 97.42K | 2.81M | -20.88K | -17.65% |
| 2023-12-31 | UBS GROUP AG | 0.19% | 92.55K | 2.67M | 48.4K | +109.64% |
| 2023-12-31 | TD ASSET MANAGEMENT INC | 0.18% | 88.72K | 2.56M | -4.39K | -4.72% |
| 2023-12-31 | BNP PARIBAS ARBITRAGE, SNC | 0.18% | 88.35K | 2.55M | 43.85K | +98.51% |
| 2023-12-31 | FMR LLC | 13.69% | 6.78M | 195.9M | 261.24K | +4.01% |
| 2023-12-31 | POINT72 ASSET MANAGEMENT, L.P. | 9.27% | 4.59M | 132.59M | 2.09M | +83.32% |
| 2023-12-31 | WELLINGTON MANAGEMENT GROUP LLP | 6.82% | 3.38M | 97.54M | 3.38M | +100.00% |
| 2023-12-31 | BLACKROCK INC. | 6.67% | 3.3M | 95.38M | 415.59K | +14.39% |
| 2023-12-31 | STATE STREET CORP | 5.17% | 2.56M | 74.05M | 767.23K | +42.70% |
| 2023-12-31 | VANGUARD GROUP INC | 4.68% | 2.32M | 67.03M | 213.64K | +10.14% |
| 2023-12-31 | PRICE T ROWE ASSOCIATES INC /MD/ | 4.49% | 2.22M | 64.19M | 141.89K | +6.82% |
| 2023-12-31 | ARTAL GROUP S.A. | 4.32% | 2.14M | 61.75M | 0 | 0 |
| 2023-12-31 | | 3.61% | 1.79M | 51.72M | 589.91K | +49.12% |
| 2023-12-31 | FEDERATED HERMES, INC. | 2.02% | 1M | 28.88M | 115.98K | +13.12% |
| 2023-12-31 | GEODE CAPITAL MANAGEMENT, LLC | 1.72% | 853.04K | 24.64M | 75.87K | +9.76% |
| 2023-12-31 | MORGAN STANLEY | 1.4% | 695.92K | 20.1M | 167.48K | +31.69% |
| 2023-12-31 | GOLDMAN SACHS GROUP INC | 1.28% | 635.06K | 18.34M | 297.57K | +88.17% |
