| 2024-03-31 | RAFFERTY ASSET MANAGEMENT, LLC | 0.37% | 218.66K | 9.47M | 97K | +79.74% |
| 2024-03-31 | BAKER BROS. ADVISORS LP | 10.81% | 6.4M | 277.24M | 0 | 0 |
| 2024-03-31 | RA CAPITAL MANAGEMENT, L.P. | 9% | 5.33M | 230.97M | 0 | 0 |
| 2024-03-31 | JGP GLOBAL GESTAO DE RECURSOS LTDA. | 0.18% | 105.81K | 4.58M | 100.13K | +1,760.30% |
| 2024-03-31 | SWISS NATIONAL BANK | 0.16% | 93.3K | 4.04M | 3.6K | +4.01% |
| 2024-03-31 | CLEARBRIDGE INVESTMENTS, LLC | 0.15% | 90K | 3.9M | -1.15K | -1.27% |
| 2024-03-31 | RICE HALL JAMES & ASSOCIATES, LLC | 0.15% | 89.73K | 3.89M | 121 | +0.14% |
| 2024-03-31 | INVESCO LTD. | 0.15% | 88.21K | 3.82M | -47.53K | -35.01% |
| 2024-03-31 | HENNION & WALSH ASSET MANAGEMENT, INC. | 0.15% | 86.97K | 3.77M | 20.26K | +30.37% |
| 2024-03-31 | RHUMBLINE ADVISERS | 0.13% | 76.72K | 3.32M | 3.55K | +4.85% |
| 2024-03-31 | WEDGE CAPITAL MANAGEMENT L L P/NC | 0.12% | 73.87K | 3.2M | -2.63K | -3.44% |
| 2024-03-31 | ALGERT GLOBAL LLC | 0.12% | 69.05K | 2.99M | 40.25K | +139.72% |
| 2024-03-31 | JEFFERIES FINANCIAL GROUP INC. | 0.12% | 68.57K | 2.97M | -13.5K | -16.45% |
| 2024-03-31 | BNP PARIBAS ARBITRAGE, SNC | 0.09% | 56.01K | 2.43M | -7.08K | -11.22% |
| 2024-03-31 | JPMORGAN CHASE & CO | 0.09% | 54.5K | 2.36M | -23.1K | -29.76% |
| 2024-03-31 | ALLIANCEBERNSTEIN L.P. | 0.09% | 53.43K | 2.32M | -960 | -1.77% |
| 2024-03-31 | INTRINSIC EDGE CAPITAL MANAGEMENT LLC | 0.08% | 50K | 2.17M | 50K | +100.00% |
| 2024-03-31 | NAN FUNG GROUP HOLDINGS LTD | 0.08% | 49.12K | 2.13M | 9.05K | +22.59% |
| 2024-03-31 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0.08% | 47.62K | 2.06M | 8.39K | +21.37% |
| 2024-03-31 | LEGAL & GENERAL GROUP PLC | 0.08% | 47.42K | 2.05B | 588 | +1.26% |
| 2024-03-31 | CREDIT SUISSE AG/ | 0.07% | 43.16K | 1.87M | 1.15K | +2.74% |
| 2024-03-31 | ALPS ADVISORS INC | 0.07% | 42.42K | 1.84M | 2.2K | +5.48% |
| 2024-03-31 | PROFUND ADVISORS LLC | 0.06% | 34.28K | 1.49B | 13.79K | +67.30% |
| 2024-03-31 | STATE OF WISCONSIN INVESTMENT BOARD | 0.06% | 33.3K | 1.44M | -4.11K | -10.99% |
| 2024-03-31 | NEW YORK STATE COMMON RETIREMENT FUND | 0.06% | 32.81K | 1.42M | -63 | -0.19% |
| 2024-03-31 | FMR LLC | 0.05% | 29.02K | 1.26M | -500.11K | -94.52% |
| 2024-03-31 | STIFEL FINANCIAL CORP | 0.05% | 27.94K | 1.21M | -2.69K | -8.78% |
| 2024-03-31 | TD ASSET MANAGEMENT INC | 0.05% | 27.6K | 1.2B | -10.2K | -26.98% |
| 2024-03-31 | PRIMECAP MANAGEMENT CO/CA/ | 13.08% | 7.75M | 335.7M | -305.06K | -3.79% |
| 2024-03-31 | PICTET ASSET MANAGEMENT HOLDING SA | 2.05% | 1.21M | 52.5M | 47.72K | +4.10% |
| 2024-03-31 | GEODE CAPITAL MANAGEMENT, LLC | 1.99% | 1.18M | 51.17M | 61.58K | +5.50% |
| 2024-03-31 | COMMODORE CAPITAL LP | 1.77% | 1.05M | 45.5M | -500K | -32.26% |
| 2024-03-31 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1.44% | 855.51K | 37.07M | 256.6K | +42.84% |
| 2024-03-31 | CHECKPOINT CAPITAL L.P. | 1.39% | 825.5K | 35.77M | 95.5K | +13.08% |
| 2024-03-31 | HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1.23% | 730.64K | 31.66M | 578.8K | +381.18% |
| 2024-03-31 | ORBIMED ADVISORS LLC | 1.19% | 704.84K | 30.54M | 168.2K | +31.34% |
| 2024-03-31 | JANUS HENDERSON GROUP PLC | 1.05% | 621.43K | 26.93M | -465 | -0.07% |
| 2024-03-31 | CANADA PENSION PLAN INVESTMENT BOARD | 0.97% | 577K | 25M | 310K | +116.10% |
| 2024-03-31 | CORMORANT ASSET MANAGEMENT, LP | 0.93% | 550K | 23.83M | 0 | 0 |
| 2024-03-31 | OPALEYE MANAGEMENT INC. | 0.87% | 515K | 22.31M | -95K | -15.57% |
| 2024-03-31 | PRICE T ROWE ASSOCIATES INC /MD/ | 0.81% | 481.53K | 20.87M | -90.76K | -15.86% |
| 2024-03-31 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0.8% | 473.46K | 20.51M | 110.74K | +30.53% |
| 2024-03-31 | CAPTION MANAGEMENT, LLC | 0.71% | 419.3K | 18.17M | -52.4K | -11.11% |
| 2024-03-31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.69% | 406.75K | 17.62M | 9.06K | +2.28% |
| 2024-03-31 | NATIONAL BANK OF CANADA /FI/ | 0.62% | 367.52K | 14.38M | 128.52K | +53.77% |
| 2024-03-31 | ASSENAGON ASSET MANAGEMENT S.A. | 0.48% | 285.65K | 12.38M | -15.99K | -5.30% |
| 2024-03-31 | LORD, ABBETT & CO. LLC | 0.47% | 281.16K | 12.18M | -2.36K | -0.83% |
| 2024-03-31 | ARTISAN PARTNERS LIMITED PARTNERSHIP | 0.46% | 271.42K | 11.76M | 0 | 0 |
| 2024-03-31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.44% | 262.7K | 11.38M | -8.3K | -3.06% |
| 2024-03-31 | FRANKLIN RESOURCES INC | 0.37% | 220.91K | 9.57M | 215.03K | +3,659.45% |
| 2024-03-31 | VANGUARD GROUP INC | 5.58% | 3.3M | 143.17M | 77.21K | +2.39% |
| 2024-03-31 | PERCEPTIVE ADVISORS LLC | 5.52% | 3.27M | 141.63M | 1.11M | +51.74% |
| 2024-03-31 | STATE STREET CORP | 5.09% | 3.01M | 130.59M | 807.82K | +36.62% |
| 2024-03-31 | FEDERATED HERMES, INC. | 2.81% | 1.66M | 71.98M | -649.86K | -28.12% |
| 2024-03-31 | BLACKROCK INC. | 11.03% | 6.53M | 282.93M | 177.9K | +2.80% |
| 2024-03-31 | GOLDMAN SACHS GROUP INC | 8.63% | 5.11M | 221.49M | 63.67K | +1.26% |
| 2024-03-31 | NEA MANAGEMENT COMPANY, LLC | 4.91% | 2.91M | 126.09M | 0 | 0 |
| 2024-03-31 | FRAZIER LIFE SCIENCES MANAGEMENT, L.P. | 3.7% | 2.19M | 94.9M | -181.13K | -7.64% |
| 2024-03-31 | ROCK SPRINGS CAPITAL MANAGEMENT LP | 2.57% | 1.52M | 65.99M | 0 | 0 |
| 2024-03-31 | POLAR CAPITAL HOLDINGS PLC | 2.53% | 1.5M | 65M | -250K | -14.29% |
| 2024-03-31 | NORTHERN TRUST CORP | 0.85% | 502.86K | 21.79M | 1.76K | +0.35% |
| 2024-03-31 | UBS ASSET MANAGEMENT AMERICAS INC | 0.35% | 206.98K | 8.97M | -2.96K | -1.41% |
| 2024-03-31 | WELLINGTON MANAGEMENT GROUP LLP | 0.33% | 193.52K | 8.39M | 53.72K | +38.43% |
| 2024-03-31 | CITIGROUP INC | 0.32% | 190.52K | 8.26M | 136.22K | +250.87% |
| 2024-03-31 | SILVERARC CAPITAL MANAGEMENT, LLC | 0.31% | 183.78K | 7.96M | 9.53K | +5.47% |
| 2024-03-31 | MORGAN STANLEY | 0.31% | 182.87K | 7.92M | -48.79K | -21.06% |
| 2024-03-31 | SAMSARA BIOCAPITAL, LLC | 0.29% | 172.65K | 7.48M | 0 | 0 |
| 2024-03-31 | WOODLINE PARTNERS LP | 0.29% | 172.21K | 7.46M | 97.36K | +130.07% |
| 2024-03-31 | UBS GROUP AG | 0.29% | 171.57K | 7.43M | 85.61K | +99.60% |
| 2024-03-31 | VOYA INVESTMENT MANAGEMENT LLC | 0.29% | 169.71K | 7.35M | 104.72K | +161.13% |
| 2024-03-31 | BANK OF NEW YORK MELLON CORP | 0.28% | 167.84K | 7.27M | -12.38K | -6.87% |
| 2024-03-31 | NISA INVESTMENT ADVISORS, LLC | 0.25% | 145.29K | 6.3M | 144.04K | +11,467.75% |
| 2024-03-31 | NUVEEN ASSET MANAGEMENT, LLC | 0.24% | 142.74K | 6.18M | -934 | -0.65% |
| 2024-03-31 | BARCLAYS PLC | 0.22% | 127.54K | 5.53M | -123.88K | -49.27% |
| 2024-03-31 | GHOST TREE CAPITAL, LLC | 0.21% | 125K | 5.42M | 125K | +100.00% |
| 2023-12-31 | BAKER BROS. ADVISORS LP | 11.06% | 6.4M | 294.13M | -303.98K | -4.54% |
| 2023-12-31 | BLACKROCK INC. | 10.98% | 6.35M | 291.99M | 151.87K | +2.45% |
| 2023-12-31 | RA CAPITAL MANAGEMENT, L.P. | 9.21% | 5.33M | 245.04M | -345.66K | -6.09% |
| 2023-12-31 | GOLDMAN SACHS GROUP INC | 8.72% | 5.05M | 232.05M | -112.61K | -2.18% |
| 2023-12-31 | VANGUARD GROUP INC | 5.58% | 3.23M | 148.34M | 212.37K | +7.04% |
| 2023-12-31 | NEA MANAGEMENT COMPANY, LLC | 5.03% | 2.91M | 133.77M | 0 | 0 |
| 2023-12-31 | FRAZIER LIFE SCIENCES MANAGEMENT, L.P. | 4.1% | 2.37M | 109.01M | 0 | 0 |
| 2023-12-31 | FEDERATED HERMES, INC. | 3.99% | 2.31M | 106.23M | -30.38K | -1.30% |
| 2023-12-31 | STATE STREET CORP | 3.81% | 2.21M | 101.41M | -159.84K | -6.76% |
| 2023-12-31 | PERCEPTIVE ADVISORS LLC | 3.72% | 2.15M | 99.02M | 1.77M | +465.64% |
| 2023-12-31 | POLAR CAPITAL HOLDINGS PLC | 3.02% | 1.75M | 80.45M | -750K | -30.00% |
| 2023-12-31 | COMMODORE CAPITAL LP | 2.68% | 1.55M | 71.25M | -525K | -25.30% |
| 2023-12-31 | ROCK SPRINGS CAPITAL MANAGEMENT LP | 2.63% | 1.52M | 70.01M | -74.23K | -4.65% |
| 2023-12-31 | RAFFERTY ASSET MANAGEMENT, LLC | 0.21% | 121.65K | 5.59M | -41.15K | -25.28% |
| 2023-12-31 | CITADEL ADVISORS LLC | 0.2% | 113.92K | 5.24M | -141.52K | -55.40% |
| 2023-12-31 | DIMENSIONAL FUND ADVISORS LP | 0.17% | 96.95K | 4.46M | 0 | 0 |
| 2023-12-31 | PRIMECAP MANAGEMENT CO/CA/ | 13.91% | 8.05M | 370.18M | -214.77K | -2.60% |
| 2023-12-31 | | 1.26% | 730K | 33.56M | 730K | +100.00% |
| 2023-12-31 | GEODE CAPITAL MANAGEMENT, LLC | 1.93% | 1.12M | 51.45M | 74.07K | +7.09% |
| 2023-12-31 | JANUS HENDERSON GROUP PLC | 1.07% | 621.89K | 28.59M | -443.85K | -41.65% |
| 2023-12-31 | OPALEYE MANAGEMENT INC. | 1.05% | 610K | 28.04M | -43K | -6.59% |
| 2023-12-31 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1.03% | 598.91K | 27.53M | 324.38K | +118.16% |
| 2023-12-31 | PRICE T ROWE ASSOCIATES INC /MD/ | 0.99% | 572.3K | 26.31M | 361.95K | +172.07% |
| 2023-12-31 | CORMORANT ASSET MANAGEMENT, LP | 0.95% | 550K | 25.28M | -300K | -35.29% |
| 2023-12-31 | ORBIMED ADVISORS LLC | 0.93% | 536.64K | 24.67M | -47K | -8.05% |
| 2023-12-31 | FMR LLC | 0.91% | 529.13K | 24.32M | -339.34K | -39.07% |
| 2023-12-31 | NORTHERN TRUST CORP | 0.87% | 501.09K | 23.04M | -2.93K | -0.58% |
| 2023-12-31 | VR ADVISER, LLC | 0.86% | 495.98K | 22.8M | -594.02K | -54.50% |
| 2023-12-31 | CAPTION MANAGEMENT, LLC | 0.82% | 471.7K | 21.68M | 471.7K | +100.00% |
| 2023-12-31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.69% | 397.69K | 18.28M | 12.94K | +3.36% |
| 2023-12-31 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0.63% | 362.72K | 16.67M | 342.35K | +1,680.91% |
| 2023-12-31 | ASSENAGON ASSET MANAGEMENT S.A. | 0.52% | 301.64K | 13.87M | -105.65K | -25.94% |
| 2023-12-31 | LORD, ABBETT & CO. LLC | 0.49% | 283.52K | 13.03M | 283.52K | +100.00% |
| 2023-12-31 | ARTISAN PARTNERS LIMITED PARTNERSHIP | 0.47% | 271.42K | 12.48M | 271.42K | +100.00% |
| 2023-12-31 | CANADA PENSION PLAN INVESTMENT BOARD | 0.46% | 267K | 12.27M | 267K | +100.00% |
| 2023-12-31 | BARCLAYS PLC | 0.43% | 251.42K | 11.56M | 10.15K | +4.21% |
| 2023-12-31 | NATIONAL BANK OF CANADA /FI/ | 0.41% | 239K | 10.79M | 108K | +82.44% |
| 2023-12-31 | MORGAN STANLEY | 0.4% | 231.66K | 10.65M | -204.75K | -46.92% |
| 2023-12-31 | UBS ASSET MANAGEMENT AMERICAS INC | 0.36% | 209.94K | 9.65M | -127.33K | -37.75% |
| 2023-12-31 | JANE STREET GROUP, LLC | 0.32% | 184.36K | 8.47M | 40.36K | +28.03% |
| 2023-12-31 | VICTORY CAPITAL MANAGEMENT INC | 0.32% | 182.3K | 8.38M | 162.25K | +809.21% |
| 2023-12-31 | BANK OF NEW YORK MELLON CORP | 0.31% | 180.22K | 8.28M | 2.85K | +1.60% |
| 2023-12-31 | SILVERARC CAPITAL MANAGEMENT, LLC | 0.3% | 174.25K | 8.01M | -86.29K | -33.12% |
| 2023-12-31 | SAMSARA BIOCAPITAL, LLC | 0.3% | 172.65K | 7.94M | -172.65K | -50.00% |
| 2023-12-31 | HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0.26% | 151.84K | 6.98M | -25.16K | -14.21% |
| 2023-12-31 | NUVEEN ASSET MANAGEMENT, LLC | 0.25% | 143.67K | 6.6M | 2.08K | +1.47% |
| 2023-12-31 | WELLINGTON MANAGEMENT GROUP LLP | 0.24% | 139.8K | 6.43M | 139.8K | +100.00% |
| 2023-12-31 | INVESCO LTD. | 0.23% | 135.73K | 6.24M | 107.36K | +378.36% |
| 2023-12-31 | D. E. SHAW & CO., INC. | 0.22% | 128.49K | 5.91M | 128.49K | +100.00% |
