| 2024-03-31 | PARADIGM BIOCAPITAL ADVISORS LP | 11.24% | 5.03M | 88.1M | 236.93K | +4.94% |
| 2024-03-31 | STATE OF WISCONSIN INVESTMENT BOARD | 0.05% | 22.27K | 389.95K | -36.06K | -61.82% |
| 2024-03-31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.05% | 21.2K | 371.21K | 21.2K | +100.00% |
| 2024-03-31 | E FUND MANAGEMENT CO., LTD. | 0.04% | 19.32K | 338.35K | 8.45K | +77.68% |
| 2024-03-31 | INVESCO LTD. | 0.04% | 18.73K | 327.96K | -126.04K | -87.06% |
| 2024-03-31 | NEW YORK STATE COMMON RETIREMENT FUND | 0.04% | 17.95K | 314K | 451 | +2.58% |
| 2024-03-31 | PRINCIPAL FINANCIAL GROUP INC | 0.03% | 11.92K | 208.63K | 1.06K | +9.74% |
| 2024-03-31 | RAYMOND JAMES & ASSOCIATES | 0.03% | 11.55K | 202.22K | 1.32K | +12.92% |
| 2024-03-31 | ARIZONA STATE RETIREMENT SYSTEM | 0.03% | 11.49K | 201.19K | 1.96K | +20.53% |
| 2024-03-31 | DIMENSIONAL FUND ADVISORS LP | 0.02% | 10.07K | 176.33K | 0 | 0 |
| 2024-03-31 | STATE STREET CORP | 10.03% | 4.49M | 78.6M | 1.78M | +65.73% |
| 2024-03-31 | VR ADVISER, LLC | 8.68% | 3.88M | 67.99M | 48 | 0.00% |
| 2024-03-31 | NOVO HOLDINGS A/S | 2.46% | 1.1M | 19.26M | 1.1M | +100.00% |
| 2024-03-31 | PICTET ASSET MANAGEMENT HOLDING SA | 2.45% | 1.1M | 19.18M | 44.57K | +4.24% |
| 2024-03-31 | CITADEL ADVISORS LLC | 1.7% | 762.41K | 13.35M | -124.23K | -14.01% |
| 2024-03-31 | FISHER ASSET MANAGEMENT, LLC | 0.87% | 389.09K | 6.81M | 389.09K | +100.00% |
| 2024-03-31 | YIHENG CAPITAL MANAGEMENT, L.P. | 2.12% | 948.13K | 16.6M | -280.4K | -22.82% |
| 2024-03-31 | POLAR CAPITAL HOLDINGS PLC | 1.99% | 889.2K | 15.57M | -90.72K | -9.26% |
| 2024-03-31 | 5AM VENTURE MANAGEMENT, LLC | 1.65% | 736.6K | 12.9M | 150K | +25.57% |
| 2024-03-31 | LOGOS GLOBAL MANAGEMENT LP | 1.56% | 700K | 12.26M | 100K | +16.67% |
| 2024-03-31 | TANG CAPITAL MANAGEMENT LLC | 1.55% | 692.93K | 12.13M | 0 | 0 |
| 2024-03-31 | GHOST TREE CAPITAL, LLC | 1.4% | 625K | 10.94M | 325K | +108.33% |
| 2024-03-31 | OCTAGON CAPITAL ADVISORS LP | 1.39% | 620K | 10.86M | 0 | 0 |
| 2024-03-31 | BIOIMPACT CAPITAL LLC | 1.37% | 614.01K | 10.75M | 514.01K | +514.01% |
| 2024-03-31 | RTW INVESTMENTS, LP | 1.35% | 605.82K | 10.61M | 0 | 0 |
| 2024-03-31 | MORGAN STANLEY | 1.26% | 562.54K | 9.85M | 37.64K | +7.17% |
| 2024-03-31 | GOLDMAN SACHS GROUP INC | 1.21% | 543.14K | 9.51M | 161.4K | +42.28% |
| 2024-03-31 | WOODLINE PARTNERS LP | 0.98% | 438.92K | 7.69M | 438.92K | +100.00% |
| 2024-03-31 | EAGLE ASSET MANAGEMENT INC | 0.98% | 438.77K | 7.57M | -14.54K | -3.21% |
| 2024-03-31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.95% | 424.09K | 7.43M | 52.77K | +14.21% |
| 2024-03-31 | RAFFERTY ASSET MANAGEMENT, LLC | 0.91% | 408.89K | 7.16M | 206.4K | +101.93% |
| 2024-03-31 | UBS GROUP AG | 0.85% | 379.58K | 6.65M | 236.2K | +164.73% |
| 2024-03-31 | CITIGROUP INC | 0.78% | 347.91K | 6.09M | 263.63K | +312.77% |
| 2024-03-31 | SOLEUS CAPITAL MANAGEMENT, L.P. | 0.76% | 340K | 5.95M | 202K | +146.38% |
| 2024-03-31 | RUSSELL INVESTMENTS GROUP, LTD. | 0.72% | 321.61K | 5.63M | -7.88K | -2.39% |
| 2024-03-31 | TWO SIGMA ADVISERS, LP | 0.68% | 304.4K | 5.33M | 204.1K | +203.49% |
| 2024-03-31 | ROSALIND ADVISORS, INC. | 0.67% | 300K | 5.25M | -60.33K | -16.74% |
| 2024-03-31 | CUTTER CAPITAL MANAGEMENT, LP | 0.62% | 278.64K | 4.88M | -29.08K | -9.45% |
| 2024-03-31 | RENAISSANCE TECHNOLOGIES LLC | 0.58% | 261.7K | 4.58M | 248.3K | +1,852.99% |
| 2024-03-31 | WELLINGTON MANAGEMENT GROUP LLP | 0.54% | 240.83K | 4.22M | 48.73K | +25.37% |
| 2024-03-31 | TWO SIGMA INVESTMENTS, LP | 0.51% | 226.85K | 3.97M | 226.85K | +100.00% |
| 2024-03-31 | KOPP LEROY C | 0.46% | 205.64K | 3.6M | 205.64K | +100.00% |
| 2024-03-31 | KOPP FAMILY OFFICE, LLC | 0.46% | 205.64K | 3.6M | 40 | +0.02% |
| 2024-03-31 | FMR LLC | 21.04% | 9.42M | 164.86M | 1.79M | +23.47% |
| 2024-03-31 | BLACKROCK INC. | 8.52% | 3.81M | 66.76M | 386.18K | +11.27% |
| 2024-03-31 | VANGUARD GROUP INC | 7.23% | 3.23M | 56.63M | 233.33K | +7.78% |
| 2024-03-31 | ALLIANCEBERNSTEIN L.P. | 3.85% | 1.72M | 30.17M | -336.65K | -16.35% |
| 2024-03-31 | BANK OF AMERICA CORP /DE/ | 1.06% | 475.73K | 8.33M | 189.29K | +66.08% |
| 2024-03-31 | NORTHERN TRUST CORP | 1.03% | 462.68K | 8.1M | 49.04K | +11.86% |
| 2024-03-31 | PERCEPTIVE ADVISORS LLC | 8.17% | 3.66M | 64.04M | 1.93M | +111.37% |
| 2024-03-31 | DEEP TRACK CAPITAL, LP | 7.72% | 3.46M | 60.52M | -175.68K | -4.84% |
| 2024-03-31 | MAVERICK CAPITAL LTD | 6.02% | 2.69M | 47.14M | 366.57K | +15.76% |
| 2024-03-31 | COMMODORE CAPITAL LP | 4.32% | 1.93M | 33.88M | 10.58K | +0.55% |
| 2024-03-31 | FAIRMOUNT FUNDS MANAGEMENT LLC | 4.12% | 1.85M | 32.32M | 476.19K | +34.77% |
| 2024-03-31 | VIVO CAPITAL, LLC | 3.75% | 1.68M | 29.39M | 0 | 0 |
| 2024-03-31 | GREAT POINT PARTNERS LLC | 2.98% | 1.34M | 23.38M | 1.34M | +100.00% |
| 2024-03-31 | NUVEEN ASSET MANAGEMENT, LLC | 2.98% | 1.33M | 23.33M | 1.1M | +469.72% |
| 2024-03-31 | GEODE CAPITAL MANAGEMENT, LLC | 2.6% | 1.16M | 20.39M | 169.8K | +17.07% |
| 2024-03-31 | CANDRIAM S.C.A. | 0.63% | 280K | 4.9M | 280K | +100.00% |
| 2024-03-31 | BANK OF NEW YORK MELLON CORP | 0.34% | 151.86K | 2.66M | 2.05K | +1.37% |
| 2024-03-31 | EVERSEPT PARTNERS, LP | 0.32% | 142.08K | 2.49M | 4.73K | +3.45% |
| 2024-03-31 | HENNION & WALSH ASSET MANAGEMENT, INC. | 0.25% | 109.82K | 1.92M | 34.04K | +44.92% |
| 2024-03-31 | SWISS NATIONAL BANK | 0.19% | 82.9K | 1.45M | 15.7K | +23.36% |
| 2024-03-31 | KNIGHTS OF COLUMBUS ASSET ADVISORS LLC | 0.18% | 78.82K | 1.38M | -75.13K | -48.80% |
| 2024-03-31 | RHUMBLINE ADVISERS | 0.15% | 67.52K | 1.18M | 7.09K | +11.73% |
| 2024-03-31 | PROFUND ADVISORS LLC | 0.14% | 63.01K | 1.1B | 30.02K | +90.99% |
| 2024-03-31 | JPMORGAN CHASE & CO | 0.11% | 49.02K | 858.39K | -7.92K | -13.90% |
| 2024-03-31 | CREDIT SUISSE AG/ | 0.11% | 47.88K | 838.33K | 6.81K | +16.59% |
| 2024-03-31 | ALPS ADVISORS INC | 0.1% | 44.28K | 775.27K | 9.42K | +27.03% |
| 2024-03-31 | LEGAL & GENERAL GROUP PLC | 0.09% | 39.09K | 684.41M | 4.52K | +13.08% |
| 2024-03-31 | ALGERT GLOBAL LLC | 0.08% | 37.82K | 662K | 37.82K | +100.00% |
| 2024-03-31 | WELLS FARGO & COMPANY/MN | 0.07% | 32.13K | 562.56K | 6.24K | +24.08% |
| 2024-03-31 | MIRAE ASSET GLOBAL INVESTMENTS CO., LTD. | 0.06% | 28.82K | 628.68K | 1.14K | +4.10% |
| 2024-03-31 | LIGHTHOUSE INVESTMENT PARTNERS, LLC | 0.06% | 28.41K | 497.39K | 28.41K | +100.00% |
| 2024-03-31 | STONECREST WEALTH MANAGEMENT, INC. | 0.06% | 27.68K | 484.59K | -116 | -0.42% |
| 2024-03-31 | METLIFE INVESTMENT MANAGEMENT, LLC | 0.06% | 25.57K | 447.73K | 3.3K | +14.81% |
| 2024-03-31 | AMERICAN INTERNATIONAL GROUP, INC. | 0.05% | 24.52K | 429.26K | 3.27K | +15.37% |
| 2024-03-31 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0.05% | 24.24K | 424.39K | 8.18K | +50.96% |
| 2023-12-31 | FMR LLC | 17.47% | 7.63M | 166.08M | 7.36M | +2,808.43% |
| 2023-12-31 | PARADIGM BIOCAPITAL ADVISORS LP | 10.98% | 4.79M | 104.42M | 1.11M | +30.22% |
| 2023-12-31 | VR ADVISER, LLC | 8.89% | 3.88M | 84.56M | 800K | +25.95% |
| 2023-12-31 | DEEP TRACK CAPITAL, LP | 8.32% | 3.63M | 79.1M | 668.46K | +22.56% |
| 2023-12-31 | BLACKROCK INC. | 7.85% | 3.43M | 74.63M | 433.39K | +14.48% |
| 2023-12-31 | VANGUARD GROUP INC | 6.87% | 3M | 65.36M | 552.93K | +22.59% |
| 2023-12-31 | STATE STREET CORP | 6.2% | 2.71M | 58.99M | -233.31K | -7.93% |
| 2023-12-31 | MAVERICK CAPITAL LTD | 5.33% | 2.33M | 50.66M | 2.33M | +100.00% |
| 2023-12-31 | ALLIANCEBERNSTEIN L.P. | 4.72% | 2.06M | 44.86M | 168.47K | +8.91% |
| 2023-12-31 | PERCEPTIVE ADVISORS LLC | 3.96% | 1.73M | 37.68M | 719.01K | +71.10% |
| 2023-12-31 | VIVO CAPITAL, LLC | 3.84% | 1.68M | 36.55M | 0 | 0 |
| 2023-12-31 | FAIRMOUNT FUNDS MANAGEMENT LLC | 3.14% | 1.37M | 29.83M | 0 | 0 |
| 2023-12-31 | YIHENG CAPITAL MANAGEMENT, L.P. | 2.81% | 1.23M | 26.76M | 0 | 0 |
| 2023-12-31 | | 0.7% | 307.72K | 6.7M | 307.72K | +100.00% |
| 2023-12-31 | GEODE CAPITAL MANAGEMENT, LLC | 2.28% | 994.47K | 21.66M | 135.37K | +15.76% |
| 2023-12-31 | POLAR CAPITAL HOLDINGS PLC | 2.24% | 979.92K | 21.34M | -620.08K | -38.76% |
| 2023-12-31 | CITADEL ADVISORS LLC | 2.03% | 886.64K | 19.31M | 784.21K | +765.60% |
| 2023-12-31 | TANG CAPITAL MANAGEMENT LLC | 1.59% | 692.93K | 15.09M | 23.8K | +3.56% |
| 2023-12-31 | OCTAGON CAPITAL ADVISORS LP | 1.42% | 620K | 13.5M | -447.14K | -41.90% |
| 2023-12-31 | KYNAM CAPITAL MANAGEMENT, LP | 1.39% | 607.92K | 13.24M | -91.77K | -13.12% |
| 2023-12-31 | RTW INVESTMENTS, LP | 1.39% | 605.82K | 13.19M | 605.82K | +100.00% |
| 2023-12-31 | LOGOS GLOBAL MANAGEMENT LP | 1.37% | 600K | 13.07M | -450K | -42.86% |
| 2023-12-31 | 5AM VENTURE MANAGEMENT, LLC | 1.34% | 586.6K | 12.78M | 176.6K | +43.07% |
| 2023-12-31 | JEFFERIES FINANCIAL GROUP INC. | 1.24% | 540.67K | 11.78M | 540.67K | +100.00% |
| 2023-12-31 | MORGAN STANLEY | 1.2% | 524.9K | 11.43M | 191.18K | +57.29% |
| 2023-12-31 | EAGLE ASSET MANAGEMENT INC | 1.04% | 453.31K | 9.87M | -5.86K | -1.28% |
| 2023-12-31 | NORTHERN TRUST CORP | 0.95% | 413.64K | 9.01M | 11.98K | +2.98% |
| 2023-12-31 | GOLDMAN SACHS GROUP INC | 0.87% | 381.74K | 8.31M | -17.54K | -4.39% |
| 2023-12-31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.85% | 371.31K | 8.09M | 58.09K | +18.55% |
| 2023-12-31 | ROSALIND ADVISORS, INC. | 0.83% | 360.33K | 7.85M | 360.33K | +100.00% |
| 2023-12-31 | RUSSELL INVESTMENTS GROUP, LTD. | 0.75% | 329.48K | 7.18M | 30.34K | +10.14% |
| 2023-12-31 | BRAIDWELL LP | 0.74% | 323.1K | 7.04M | -1.41M | -81.38% |
| 2023-12-31 | MARSHALL WACE, LLP | 0.69% | 301.29K | 6.56M | -661.2K | -68.70% |
| 2023-12-31 | GHOST TREE CAPITAL, LLC | 0.69% | 300K | 6.53M | 25K | +9.09% |
| 2023-12-31 | BANK OF AMERICA CORP /DE/ | 0.66% | 286.45K | 6.24M | 81.23K | +39.58% |
| 2023-12-31 | ACUTA CAPITAL PARTNERS, LLC | 0.64% | 281.5K | 6.13M | 57.16K | +25.48% |
| 2023-12-31 | WALLEYE CAPITAL LLC | 0.55% | 241.41K | 5.26M | 227.88K | +1,684.26% |
| 2023-12-31 | NUVEEN ASSET MANAGEMENT, LLC | 0.54% | 233.88K | 5.09M | 30.44K | +14.96% |
| 2023-12-31 | MILLENNIUM MANAGEMENT LLC | 0.51% | 224.79K | 4.9M | -1.16M | -83.72% |
| 2023-12-31 | BARCLAYS PLC | 0.5% | 219.59K | 4.78M | 88.04K | +66.92% |
| 2023-12-31 | KOPP FAMILY OFFICE, LLC | 0.47% | 205.6K | 4.48M | -8.69K | -4.06% |
| 2023-12-31 | RAFFERTY ASSET MANAGEMENT, LLC | 0.46% | 202.49K | 4.41M | -59.81K | -22.80% |
| 2023-12-31 | HIGHVISTA STRATEGIES LLC | 0.45% | 198.48K | 4.32M | 93.73K | +89.47% |
| 2023-12-31 | WELLINGTON MANAGEMENT GROUP LLP | 0.44% | 192.1K | 4.18M | 192.1K | +100.00% |
| 2023-12-31 | SCHONFELD STRATEGIC ADVISORS LLC | 0.41% | 178.92K | 3.9M | 70.88K | +65.61% |
| 2023-12-31 | POLAR ASSET MANAGEMENT PARTNERS INC. | 0.37% | 159.7K | 3.48M | 83.1K | +108.49% |
| 2023-12-31 | KNIGHTS OF COLUMBUS ASSET ADVISORS LLC | 0.35% | 153.95K | 3.35M | 124.4K | +420.93% |
| 2023-12-31 | COMMODORE CAPITAL LP | 4.41% | 1.92M | 41.91M | -275.93K | -12.54% |
